New Trends and Future Opportunities in the Enzymatic Formation of C− C, C− N, and C− O bonds

JJ Sangster, JR Marshall, NJ Turner… - …, 2022 - Wiley Online Library
Organic chemistry provides society with fundamental products we use daily. Concerns about
the impact that the chemical industry has over the environment is propelling major changes …

Biocatalysis making waves in organic chemistry

U Hanefeld, F Hollmann, CE Paul - Chemical Society Reviews, 2022 - pubs.rsc.org
Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

New chemistry from natural product biosynthesis

CB Hubert, SM Barry - Biochemical Society Transactions, 2016 - portlandpress.com
Catalysts are a vital part of synthetic chemistry. However, there are still many important
reactions for which catalysts have not been developed. The use of enzymes as biocatalysts …

Broadening the scope of biocatalytic C–C bond formation

LE Zetzsche, ARH Narayan - Nature Reviews Chemistry, 2020 - nature.com
Enzymes exercise impeccable control over chemoselectivity, site selectivity and
stereoselectivity in reactions they mediate, such that we have witnessed a surge in the …

Enzyme mediated C C bond formation

WD Fessner - Current opinion in chemical biology, 1998 - Elsevier
A number of significant biocatalysts have been investigated over the past year to improve
accessibility, functional knowledge and use in developing synthetic applications. In …

Building bridges: Biocatalytic C–C-bond formation toward multifunctional products

NG Schmidt, E Eger, W Kroutil - ACS catalysis, 2016 - ACS Publications
Carbon–carbon bond formation is the key reaction for organic synthesis to construct the
carbon framework of organic molecules. The review gives a selection of biocatalytic C–C …

[HTML][HTML] Expanding the synthetic scope of biocatalysis by enzyme discovery and protein engineering

JR Marshall, J Mangas-Sanchez, NJ Turner - Tetrahedron, 2021 - Elsevier
Despite the growing impact of enzyme catalysis in industrial chemistry, the full potential of
this technology is yet to be unlocked. Accessing new chemistries and expanding the scope …

Catalyst-free and additive-free reactions enabling C–C bond formation: a journey towards a sustainable future

B Baruah, ML Deb - Organic & Biomolecular Chemistry, 2021 - pubs.rsc.org
This review focuses on the catalyst-and additive-free C–C bond forming reactions reported
mostly from the year 2005 to date. C–C bond forming reactions are highly important as large …

[HTML][HTML] Novel carbon–carbon bond formations for biocatalysis

V Resch, JH Schrittwieser, E Siirola, W Kroutil - Current opinion in …, 2011 - Elsevier
Carbon–carbon bond formation is the key transformation in organic synthesis to set up the
carbon backbone of organic molecules. However, only a limited number of enzymatic C–C …

Looking back: a short history of the discovery of enzymes and how they became powerful chemical tools

CM Heckmann, F Paradisi - ChemCatChem, 2020 - Wiley Online Library
Enzymatic approaches to challenges in chemical synthesis are increasingly popular and
very attractive to industry given their green nature and high efficiency compared to traditional …