A decline in energy is common in aging, and the restoration of mitochondrial bioenergetics
may offer a common approach for the treatment of numerous age‐associated diseases …

Background and Purpose Cardiolipin plays an important role in mitochondrial respiration
and cardiolipin peroxidation is associated with age‐related diseases. Hydrophobic …

The mitochondrial electron transport chain (ETC) plays a central role in energy generation in
the cell. Mitochondrial dysfunctions diminish adenosine triphosphate (ATP) production and …

It has been proposed that a loss of bioenergetic capacity of cells contributes to the
progressive loss of biological function with age. Aging is associated with loss of …

Cardiolipin (CL) is a unique phospholipid that is almost exclusively localized at the level of
the inner mitochondrial membrane (IMM), where it is biosynthesized. This phospholipid is …

Mitochondrial dysfunction underlies the etiology of a broad spectrum of diseases including
heart disease, cancer, neurodegenerative diseases, and the general aging process …

The present review is an attempt to conceptualize a contemporary understanding about the
roles that cardiolipin, a mitochondrial specific conical phospholipid, and non-bilayer …

In eukaryotic cells, mitochondria are involved in a large array of metabolic and bioenergetic
processes that are vital for cell survival. Phospholipids are the main building blocks of …

Ischemia causes AKI as a result of ATP depletion, and rapid recovery of ATP on reperfusion
is important to minimize tissue damage. ATP recovery is often delayed, however, because …

Mitochondria play an essential role in the energy metabolism of the heart. Many of the
essential functions are associated with mitochondrial membranes and oxidative …