The serotonin hypothesis of depression has played an important role in the history of
psychiatry, yet it has also been criticized for the delayed onset and inadequate efficacy of …

Serotonin modulates neuroplasticity, especially during early life, and dysfunctions in both
systems likewise contribute to pathophysiology of depression. Recent findings demonstrate …

It is widely accepted that changes underlying depression and antidepressant‐like effects
involve not only alterations in the levels of neurotransmitters as monoamines and their …

Major depression is a chronic, recurring and potentially life-threatening illness that affects up
to 10% of the population worldwide. Pharmacological and genetic studies highlight the …

Depressive disorders are heterogeneous diseases, and the complexity of symptoms has led
to the formulation of several aethiopathological hypotheses. This heterogeneity may account …

Depression is a common and debilitating mental health condition whose underlying
aetiology and pathophysiology is still relatively poorly understood. In this article, we first turn …

Depression is a common chronic psychiatric disorder that is also often co-morbid with
numerous neurological and immune diseases. Accumulating evidence indicates that …

Since the 1960s, when the first tricyclic and monoamine oxidase inhibitor antidepressant
drugs were introduced, most of the ensuing agents were designed to target similar brain …

Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …

The pathophysiology of depression has been traditionally attributed to a chemical imbalance
and critical interactions between genetic and environmental risk factors, and antidepressant …