Parkinson's disease: etiology, neuropathology, and pathogenesis

A Kouli, KM Torsney, WL Kuan - Exon Publications, 2018 - exonpublications.com
Parkinson's disease (PD) is a common neurodegenerative disorder. While a number of
nonmotor manifestations arise, the typical clinical features involve a movement disorder …

What genetics tells us about the causes and mechanisms of Parkinson's disease

O Corti, S Lesage, A Brice - Physiological reviews, 2011 - journals.physiology.org
Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …

Epidemiology of Parkinson's disease

OB Tysnes, A Storstein - Journal of neural transmission, 2017 - Springer
Parkinson's disease (PD) affects 1–2 per 1000 of the population at any time. PD prevalence
is increasing with age and PD affects 1% of the population above 60 years. The main …

Mitochondrial involvement in Parkinson's disease

M Orth, AHV Schapira - Neurochemistry international, 2002 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease. There is a lifetime risk of 1 in 40 for the development of PD and the …

Familial Parkinson's disease–genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease

C Schiesling, N Kieper, K Seidel… - Neuropathology and …, 2008 - Wiley Online Library
The identification of the first gene in familial Parkinson's disease (PD) only 10 years ago was
a major step in the understanding of the molecular mechanisms in neurodegeneration …

Neuropathology of Parkinson disease

DW Dickson - Parkinsonism & related disorders, 2018 - Elsevier
Introduction Parkinson's disease (PD) is characterized by bradykinesia, rigidity, postural
instability and tremor. Several pathologic processes can produce this syndrome, but …

[HTML][HTML] Advances in the mechanisms of Parkinson's disease

CM Tolleson, JY Fang - Discovery medicine, 2013 - discoverymedicine.com
Parkinson's disease is the second most common neurodegenerative disorder. Despite fairly
typical clinical and pathologic features, the etiology remains unknown. Many cellular …

Molecular pathogenesis of Parkinson disease

JL Eriksen, Z Wszolek, L Petrucelli - Archives of neurology, 2005 - jamanetwork.com
Parkinson disease (PD), the most common neurodegenerative movement disorder, is
characterized by an extensive and progressive loss of dopaminergic neurons in the …

Parkinson's disease and parkinsonism: neuropathology

DW Dickson - Cold Spring Harbor perspectives …, 2012 - perspectivesinmedicine.cshlp.org
Parkinsonism, the clinical term for a disorder with prominent bradykinesia and variable
associated extrapyramidal signs and symptoms, is accompanied by degeneration of the …

Biology of Parkinson's disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder

GE Alexander - Dialogues in clinical neuroscience, 2004 - Taylor & Francis
Parkinson's disease (PD) is the second most common movement disorder. The
characteristic motor impairments-bradykinesia, rigidity, and resting tremor-result from …