HEROIC trials to answer pragmatic questions for hospitalized children
Although the number of randomized controlled trials (RCTs) published each year involving
adult populations is steadily rising, the annual number of RCTs published involving pediatric …
adult populations is steadily rising, the annual number of RCTs published involving pediatric …
An innovative approach to building an effective and efficient pediatric trial network
RL Randell, DK Benjamin Jr… - Hospital …, 2022 - publications.aap.org
Conducting randomized controlled trials (RCTs) in children is exceptionally challenging
because of low disease burden, ethical considerations, and limited funding. 1 The number of …
because of low disease burden, ethical considerations, and limited funding. 1 The number of …
Real-world evidence for assessing treatment effectiveness and safety in pediatric populations
DB Horton, MD Blum, M Burcu - The Journal of Pediatrics, 2021 - jpeds.com
The race for effective treatments against coronavirus disease 2019 has reminded
pediatricians of historical delays that children have faced in drug development and clinical …
pediatricians of historical delays that children have faced in drug development and clinical …
Pediatric versus adult drug trials for conditions with high pediatric disease burden
BACKGROUND AND OBJECTIVE: Optimal treatment decisions in children require sufficient
evidence on the safety and efficacy of pharmaceuticals in pediatric patients. However, there …
evidence on the safety and efficacy of pharmaceuticals in pediatric patients. However, there …
Large pediatric randomized clinical trials in ClinicalTrials. gov
METHODS We created a bird's eye view of all large, noncluster, nonvaccine pediatric RCTs
with≥ 1000 participants registered in ClinicalTrials. gov (last search January 9, 2020). We …
with≥ 1000 participants registered in ClinicalTrials. gov (last search January 9, 2020). We …
Essential Concepts for Reducing Bias in Observational Studies
Randomized controlled trials (RCTs) are the gold standard study design for clinical
research, as prospective randomization, at least in theory, balances any differences that can …
research, as prospective randomization, at least in theory, balances any differences that can …
Meeting the demand for pediatric clinical trials
EM Connor, WE Smoyer, JM Davis, A Zajicek… - Science translational …, 2014 - science.org
Meeting the Demand for Pediatric Clinical Trials | Science Translational Medicine news careers
commentary Journals Science Science brought to you byGoogle Indexer Log in science …
commentary Journals Science Science brought to you byGoogle Indexer Log in science …
Recruiting children for clinical trials: lessons from pediatric oncology
LM Johnson, Y Unguru - The American Journal of Bioethics, 2015 - Taylor & Francis
Luchtenberg and colleagues (2015) interviewed young people in the United Kingdom who
had participated in a clinical trial to better understand their experiences and motivations as …
had participated in a clinical trial to better understand their experiences and motivations as …
High-quality randomized controlled trials in pediatric critical care: a survey of barriers and facilitators
Objectives: High-quality, adequately powered, randomized controlled trials are needed to
inform the care of critically ill children. Unfortunately, such evidence is not always available …
inform the care of critically ill children. Unfortunately, such evidence is not always available …
Prioritization of Randomized Clinical Trial Questions for Children Hospitalized With Common Conditions: A Consensus Statement
ER Coon, CE McDaniel, N Paciorkowski… - JAMA Network …, 2024 - jamanetwork.com
Importance There is a lack of randomized clinical trial (RCT) data to guide many routine
decisions in the care of children hospitalized for common conditions. A first step in …
decisions in the care of children hospitalized for common conditions. A first step in …