[HTML][HTML] The p75 Neurotrophin Receptor in Preadolescent Prefrontal Parvalbumin Interneurons Promotes Cognitive Flexibility in Adult Mice

P Chehrazi, KKY Lee, M Lavertu-Jolin, Z Abbasnejad… - Biological …, 2023 - Elsevier
Abstract Background Parvalbumin (PV)-positive GABAergic (gamma-aminobutyric acidergic)
cells provide robust perisomatic inhibition to neighboring pyramidal neurons and regulate …

p75 neurotrophin receptor in pre-adolescent prefrontal PV interneurons promotes cognitive flexibility in adult mice

P Chehrazi, KKY Lee, M Lavertu-Jolin… - bioRxiv, 2023 - biorxiv.org
Parvalbumin (PV)-positive GABAergic cells provide robust perisomatic inhibition to
neighboring pyramidal neurons and regulate brain oscillations. Alterations in PV interneuron …

p75 neurotrophin receptor activation regulates the timing of the maturation of cortical parvalbumin interneuron connectivity and promotes juvenile-like plasticity in adult …

E Baho, B Chattopadhyaya… - Journal of …, 2019 - Soc Neuroscience
By virtue of their extensive axonal arborization and perisomatic synaptic targeting, cortical
inhibitory parvalbumin (PV) cells strongly regulate principal cell output and plasticity and …

Peripuberty is a sensitive period for prefrontal parvalbumin interneuron activity to impact adult cognitive flexibility

GM Sahyoun, TD Do, A Anqueira-Gonzàlez… - Developmental …, 2024 - karger.com
Introduction: Developmental windows in which experiences can elicit long-lasting effects on
brain circuitry and behavior are called 'sensitive periods' and reflect a state of heightened …

[HTML][HTML] Reduced Anxiety-Like Behavior and Altered Hippocampal Morphology in Female p75NTRexon IV−/− Mice

Z Puschban, A Sah, I Grutsch, N Singewald… - Frontiers in Behavioral …, 2016 - frontiersin.org
The presence of the p75 neurotrophin receptor (p75NTR) in adult basal forebrain
cholinergic neurons, precursor cells in the subventricular cell layer and the subgranular cell …

Implications of p75NTR for dentate gyrus morphology and hippocampus-related behavior revisited

M Dokter, R Busch, R Poser, MA Vogt… - Brain Structure and …, 2015 - Springer
The pan-neurotrophin receptor p75NTR is expressed in the adult brain in a discrete pattern.
Although numerous studies have addressed its implications for hippocampal functions, the …

A critical role for trkB signaling in the adult function of parvalbumin interneurons and prefrontal network dynamics

N Guyon, LR Zacharias, JA van Lunteren… - bioRxiv, 2020 - biorxiv.org
Inhibitory interneurons expressing parvalbumin (PV) in the prefrontal cortex (PFC) are
central to excitatory/inhibitory (E/I) balance, generation of gamma oscillations, and cognition …

The p75 neurotrophin receptor regulates hippocampal neurogenesis and related behaviours

VS Catts, N Al‐Menhali, THJ Burne… - European Journal of …, 2008 - Wiley Online Library
Although changes to neural circuitry are believed to underlie behavioural characteristics
mediated by the hippocampus, the contribution of neurogenesis to this process remains …

Adult trkB signaling in parvalbumin interneurons is essential to prefrontal network dynamics

N Guyon, LR Zacharias, JA van Lunteren… - Journal of …, 2021 - Soc Neuroscience
Inhibitory interneurons expressing parvalbumin (PV) are central to cortical network
dynamics, generation of γ oscillations, and cognition. Dysfunction of PV interneurons …

Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period

SE Canetta, ES Holt, LJ Benoit, E Teboul, GM Sahyoun… - Elife, 2022 - elifesciences.org
In their seminal findings, Hubel and Wiesel identified sensitive periods in which experience
can exert lasting effects on adult visual cortical functioning and behavior via transient …