A journey from structure to function of bacterial lipopolysaccharides

F Di Lorenzo, KA Duda, R Lanzetta, A Silipo… - Chemical …, 2021 - ACS Publications
Lipopolysaccharide (LPS) is a crucial constituent of the outer membrane of most Gram-
negative bacteria, playing a fundamental role in the protection of bacteria from …

Lipopolysaccharide as a target for the development of novel therapeutics in gram-negative bacteria

JA Yethon, C Whitfield - Current Drug Targets-Infectious …, 2001 - ingentaconnect.com
Lipopolysaccharide (LPS) constitutes the lipid portion of the outer leaflet of Gram-negative
bacteria, and is essential for growth. LPS is also known to be responsible for the variety of …

Pushing the envelope: LPS modifications and their consequences

BW Simpson, MS Trent - Nature Reviews Microbiology, 2019 - nature.com
The defining feature of the Gram-negative cell envelope is the presence of two cellular
membranes, with the specialized glycolipid lipopolysaccharide (LPS) exclusively found on …

Function and biogenesis of lipopolysaccharides

B Bertani, N Ruiz - Ecosal plus, 2018 - Am Soc Microbiol
The cell envelope is the first line of defense between a bacterium and the world-at-large.
Often, the initial steps that determine the outcome of chemical warfare, bacteriophage …

[HTML][HTML] Structural and functional analyses of bacterial lipopolysaccharides

M Caroff, D Karibian, JM Cavaillon… - Microbes and …, 2002 - Elsevier
Bacterial lipopolysaccharides (LPSs) are powerful immunomodulators in infected hosts, and
may cause endotoxic shock. Most of them share a common architecture but vary …

[图书][B] Bacterial lipopolysaccharides: structure, chemical synthesis, biogenesis and interaction with host cells

YA Knirel, MA Valvano - 2011 - books.google.com
The bacterial lipopolysaccharide also known as endotoxin is exhaustively covered in the
present work. Central emphasis is placed upon the fine chemical structure of the …

Microbe-associated molecular patterns in innate immunity: Extraction and chemical analysis of gram-negative bacterial lipopolysaccharides

C De Castro, M Parrilli, O Holst, A Molinaro - Methods in enzymology, 2010 - Elsevier
Bacterial lipopolysaccharides (LPSs) are the major component of the outer membrane of
Gram-negative bacteria. They have a structural role since they contribute to the cellular …

Structural modifications of bacterial lipopolysaccharide that facilitate gram-negative bacteria evasion of host innate immunity

M Matsuura - Frontiers in immunology, 2013 - frontiersin.org
Bacterial lipopolysaccharide (LPS), a cell wall component characteristic of Gram-negative
bacteria, is a representative pathogen-associated molecular pattern that allows mammalian …

The dual role of lipopolysaccharide as effector and target molecule

A Wiese, K Brandenburg, AJ Ulmer, U Seydel… - 1999 - degruyter.com
Lipopolysaccharides (LPS) are major integral components of the outer membrane of Gram-
negative bacteria being exclusively located in its outer leaflet facing the bacterial …

Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors

G Zhang, V Baidin, KS Pahil… - Proceedings of the …, 2018 - National Acad Sciences
New drugs are needed to treat gram-negative bacterial infections. These bacteria are
protected by an outer membrane which prevents many antibiotics from reaching their …