Self-emulsifying drug delivery systems in oral (poly) peptide drug delivery

G Leonaviciute, A Bernkop-Schnürch - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: Oral administration of most therapeutic peptides and proteins is mainly
restricted due to the enzymatic and absorption membrane barrier of the GI tract. In order to …

Oral self-emulsifying delivery systems for systemic administration of therapeutic proteins: science fiction?

TNQ Phan, B Le-Vinh, NA Efiana… - Journal of drug …, 2019 - Taylor & Francis
Objective: The aim of this study was to develop self-emulsifying drug delivery systems
(SEDDS) for oral delivery of therapeutic proteins through hydrophobic ion pairing. Method …

Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards intestinal proteases and glutathione

G Hetényi, J Griesser, M Moser, F Demarne… - International journal of …, 2017 - Elsevier
Aim The aim of this study was to evaluate the protective effect of self-emulsifying drug
delivery systems (SEDDS) for therapeutic peptides towards intestinal proteases and …

Orally administered self-emulsifying drug delivery system in disease management: advancement and patents

V Mishra, P Nayak, N Yadav, M Singh… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: Oral administration of a drug is the most common, ideal and preferred route of
administration. The main problem of oral drug formulations is their low bioavailability arises …

Recent advances in self-emulsifying drug delivery systems (SEDDS)

B Singh, S Beg, RK Khurana… - Critical Reviews™ in …, 2014 - dl.begellhouse.com
One of the biggest challenges confronting the contemporary drug delivery science today is
to improve on the oral bioavailability of a vast number of drugs exhibiting poor and …

Oral self-nanoemulsifying peptide drug delivery systems: impact of lipase on drug release

R Mahjub, FA Dorkoosh, M Rafiee-Tehrani… - Journal of …, 2015 - Taylor & Francis
It was the aim of this study to evaluate the impact of lipases on the release behaviour of a
peptide drug from oral self-nanoemulsifying drug delivery systems. Octreotide was ion …

Development and in vitro characterization of a papain loaded mucolytic self-emulsifying drug delivery system (SEDDS)

C Leichner, C Menzel, F Laffleur… - International Journal of …, 2017 - Elsevier
The aim of the study was to create a self-emulsifying drug delivery system (SEDDS) with
mucolytic properties based on incorporated papain for improved mucus permeation. In order …

Self-emulsifying peptide drug delivery systems: How to make them highly mucus permeating

J Griesser, G Hetényi, H Kadas, F Demarne… - International journal of …, 2018 - Elsevier
Aim It was the aim of this study to evaluate the mucus permeating properties of self-
emulsifying drug delivery systems (SEDDS) exhibiting different size and zeta potential …

SEDDS: A game changing approach for the oral administration of hydrophilic macromolecular drugs

A Mahmood, A Bernkop-Schnürch - Advanced Drug Delivery Reviews, 2019 - Elsevier
Since the development of self-emulsifying drug delivery systems (SEDDS) in 1980's, they
attract the attention of researchers in order to confront the challenge of poor water-solubility …

Role of self-emulsifying drug delivery systems in optimizing the oral delivery of hydrophilic macromolecules and reducing interindividual variability

K AboulFotouh, AA Allam, M El-Badry… - Colloids and Surfaces B …, 2018 - Elsevier
Self-emulsifying drug delivery systems (SEDDS) have been widely employed to improve the
oral bioavailability of poorly soluble drugs. In the past few years, SEDDS were extensively …