Animal models are live subjects applied to translational research. They provide insights into
human diseases and enhance biomedical knowledge. Livestock production has favored the …

Different species vary in bone metabolism, especially in modeling and remodeling of the
bone. Human-related diseases with severe outcomes on bone, such as osteoporosis or …

Animal models provide important knowledge of pathological conditions that can eventually
lead to the development of more effective clinical treatment of diseases in both humans and …

Large animal models are required for preclinical prevention and intervention studies related
to osteoporosis research. The challenging aspect of this requirement is that no single animal …

Osteoporosis Research-Animal Models, presents in a very illustrative and practical manner,
general methodologies of bone studies in animals, as well as the particular features of the …

Bone is a complex tissue with a variety of functions, such as providing mechanical stability
for locomotion, protection of the inner organs, mineral homeostasis and haematopoiesis. To …

Mice have become a preferred model system for bone research because of their genetic and
pathophysiological similarities to humans: a relatively short reproductive period, leading to …

Major achievements in bone research have always relied on animal models and in vitro
systems derived from patient and animal material. However, the use of animals in research …

Osteoporosis is a chronic systemic bone disease of growing relevance due to the on-going
demographic change. Since the underlying regulatory mechanisms of this critical illness are …

The aim of the study reported here was to provide some basic and general information on
the suitability of an experimental sheep model for conducting in vivo orthopedic studies. The …