Colony stimulating factors in the nervous system
V Chitu, F Biundo, ER Stanley - Seminars in immunology, 2021 - Elsevier
Although traditionally seen as regulators of hematopoiesis, colony-stimulating factors (CSFs)
have emerged as important players in the nervous system, both in health and disease. This …
have emerged as important players in the nervous system, both in health and disease. This …
[HTML][HTML] CSF1R ligands IL-34 and CSF1 are differentially required for microglia development and maintenance in white and gray matter brain regions
C Easley-Neal, O Foreman, N Sharma… - Frontiers in …, 2019 - frontiersin.org
Microglia are specialized brain macrophages that play numerous roles in tissue
homeostasis and response to injury. Colony stimulating factor 1 receptor (CSF1R) is a …
homeostasis and response to injury. Colony stimulating factor 1 receptor (CSF1R) is a …
[HTML][HTML] The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and …
S Nandi, S Gokhan, XM Dai, S Wei, G Enikolopov… - Developmental …, 2012 - Elsevier
The CSF-1 receptor (CSF-1R) regulates CNS microglial development. However, the
localization and developmental roles of this receptor and its ligands, IL-34 and CSF-1, in the …
localization and developmental roles of this receptor and its ligands, IL-34 and CSF-1, in the …
Interkeukin‐34, a cytokine crucial for the differentiation and maintenance of tissue resident macrophages and L angerhans cells
IL‐34 is a recently discovered cytokine that acts on tissue resident macrophages and L
angerhans cells upon binding the receptor for CSF‐1, CSF‐1 R. The existence of two …
angerhans cells upon binding the receptor for CSF‐1, CSF‐1 R. The existence of two …
Colony stimulating factors and myeloid cell biology in health and disease
JA Hamilton, A Achuthan - Trends in immunology, 2013 - cell.com
The colony stimulating factors (CSFs), granulocyte macrophage-CSF (GM-CSF),
macrophage-CSF (M-CSF or CSF-1) and granulocyte-CSF (G-CSF) were first identified as in …
macrophage-CSF (M-CSF or CSF-1) and granulocyte-CSF (G-CSF) were first identified as in …
CSF-1 receptor signaling in myeloid cells
ER Stanley, V Chitu - Cold Spring Harbor perspectives …, 2014 - cshperspectives.cshlp.org
The CSF-1 receptor (CSF-1R) is activated by the homodimeric growth factors colony-
stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). It plays important roles in …
stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). It plays important roles in …
[PDF][PDF] Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia
Summary Colony stimulating factor-1 (Csf-1) receptor and its ligand Csf-1 control
macrophage development, maintenance, and function. The development of both …
macrophage development, maintenance, and function. The development of both …
[HTML][HTML] Studies on colony stimulating factor receptor-1 and ligands colony stimulating factor-1 and interleukin-34 in Alzheimer's disease brains and human microglia
DG Walker, TM Tang, LF Lue - Frontiers in aging neuroscience, 2017 - frontiersin.org
Microglia are dependent on signaling through the colony stimulating factor-1 receptor (CSF-
1R/CD115) for growth and survival. Activation of CSF-1R can lead to cell division, while …
1R/CD115) for growth and survival. Activation of CSF-1R can lead to cell division, while …
Emerging roles for CSF-1 receptor and its ligands in the nervous system
The colony-stimulating factor-1 receptor (CSF-1R) kinase regulates tissue macrophage
homeostasis, osteoclastogenesis, and Paneth cell development. However, recent studies in …
homeostasis, osteoclastogenesis, and Paneth cell development. However, recent studies in …
Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival
Colony-stimulating factor 1 (CSF1) and interleukin-34 (IL-34) are functional ligands of the
CSF1 receptor (CSF1R) and thus are key regulators of the monocyte/macrophage lineage …
CSF1 receptor (CSF1R) and thus are key regulators of the monocyte/macrophage lineage …