PI3K/Akt/mTOR pathway inhibitors in cancer: a perspective on clinical progress
P Wu, YZ Hu - Current medicinal chemistry, 2010 - ingentaconnect.com
The phosphoinositide 3-kinase (PI3K)/serine-theronine protein kinase Akt (also known as
protein kinase B (PKB))/mammalian target of rapamycin (mTOR) pathway is a vital …
protein kinase B (PKB))/mammalian target of rapamycin (mTOR) pathway is a vital …
PI3 kinase inhibitors in the clinic: an update
JE Kurtz, I Ray-Coquard - Anticancer Research, 2012 - ar.iiarjournals.org
The phosphoinositide-3 kinase/protein kinase-B/mammalian target of rapamycin
(PI3K/AKT/mTOR) pathway has been identified as a key signaling pathway for important …
(PI3K/AKT/mTOR) pathway has been identified as a key signaling pathway for important …
Targeting the PI3K/Akt/mTOR pathway in malignancy: Rationale and clinical outlook
DC Cho - BioDrugs, 2014 - Springer
Abstract The phosphatidylinositol 3-kinase (PI3K) pathway, including major downstream
effectors Akt and mammalian target of rapamycin (mTOR), plays a critical role in malignant …
effectors Akt and mammalian target of rapamycin (mTOR), plays a critical role in malignant …
Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway
CA Granville, RM Memmott, JJ Gills, PA Dennis - Clinical Cancer Research, 2006 - AACR
Abstract The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR)
pathway controls many cellular processes that are important for the formation and …
pathway controls many cellular processes that are important for the formation and …
Present and future of PI3K pathway inhibition in cancer: perspectives and limitations
Phosphoinositide 3-kinases (PI3Ks) control key signaling pathways in cancer cells, leading
to cell proliferation, survival, motility and angiogenesis. In several human cancers, activation …
to cell proliferation, survival, motility and angiogenesis. In several human cancers, activation …
Inhibitors of the PI3K/AKT/mTOR pathway in human malignancies; trend of current clinical trials
Z Davoodi-Moghaddam, F Jafari-Raddani… - Journal of Cancer …, 2023 - Springer
Abstract The phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling pathway regulates proliferation, survival and metabolism, and its dysregulation is …
signaling pathway regulates proliferation, survival and metabolism, and its dysregulation is …
Targeting the phosphoinositide 3-kinase pathway in cancer
P Liu, H Cheng, TM Roberts, JJ Zhao - Nature reviews Drug discovery, 2009 - nature.com
Abstract The phosphoinositide 3-kinase (PI3K) pathway is a key signal transduction system
that links oncogenes and multiple receptor classes to many essential cellular functions, and …
that links oncogenes and multiple receptor classes to many essential cellular functions, and …
Targeting PI3K/Akt/mTOR cascade: the medicinal potential, updated research highlights and challenges ahead
X Ma, Y Hu - Current medicinal chemistry, 2013 - ingentaconnect.com
Nowadays, cancer treatment is moving away from conventional cytotoxic drugs to target-
based agents. This is primarily attributed to some remarkable leaps made in deciphering the …
based agents. This is primarily attributed to some remarkable leaps made in deciphering the …
PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside
AS Alzahrani - Seminars in cancer biology, 2019 - Elsevier
Abstract Phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR)
signaling pathway is one of the major cellular signaling pathways that plays an important …
signaling pathway is one of the major cellular signaling pathways that plays an important …
[HTML][HTML] Current state and future challenges for PI3K inhibitors in cancer therapy
M Sirico, A D'Angelo, C Gianni, C Casadei, F Merloni… - Cancers, 2023 - mdpi.com
Simple Summary Phosphatidylinositol 3-kinase (PI3K) is a key regulator of many cellular
processes and its hyperactivation promotes tumor cell growth and survival. A broad …
processes and its hyperactivation promotes tumor cell growth and survival. A broad …