During pathogenesis, M ycobacterium tuberculosis (Mtb) colonizes environments, such as
the macrophage or necrotic granuloma, that are acidic and rich in cholesterol and fatty acids …

Mycobacterium tuberculosis (Mtb) senses and adapts to acidic host environments during the
course of pathogenesis. Mutants defective in acidic pH-dependent adaptations are often …

Mycobacterium tuberculosis (Mtb) senses and adapts to acidic environments during the
course of infection. Acidic pH-dependent adaptations include the induction of metabolic …

Metabolic adaptation to the host niche is a defining feature of the pathogenicity of
Mycobacterium tuberculosis (Mtb). In vitro, Mtb is able to grow on a variety of carbon …

Acidic pH arrests the growth of Mycobacterium tuberculosis in vitro (pH< 5.8) and is thought
to significantly contribute to the ability of macrophages to control M. tuberculosis replication …

To understand the adaptation of Mycobacterium tuberculosis to the intracellular
environment, we used comprehensive metabolite profiling to identify the biochemical …

Mycobacterium tuberculosis (Mtb) infection is difficult to treat because Mtb spends the
majority of its life cycle in a nonreplicating (NR) state. Since NR Mtb is highly tolerant to …

Recent data indicate that the nutrients available to Mycobacterium tuberculosis (Mtb) inside
its host cell are restricted in their diversity. Fatty acids and cholesterol appear more favored; …

Metabolic adaptation to the host environment is a defining feature of the pathogenicity of
Mycobacterium tuberculosis (Mtb), but we lack biochemical knowledge of its metabolic …

Mycobacterium tuberculosis (Mtb) displays a high degree of metabolic plasticity to adapt to
challenging host environments. Genetic evidence suggests that Mtb relies mainly on fatty …