Systematic pan-cancer landscape identifies CARM1 as a potential prognostic and immunological biomarker

Y Qiu, H Wang, P Liao, B Xu, R Hu, Y Yang, Y Li - BMC Genomic Data, 2022 - Springer
Background Belonging to the protein arginine methyltransferase (PRMT) family, the enzyme
encoded by coactivator associated arginine methyltransferase 1 (CARM1) catalyzes the …

The emerging role of CARM1 in cancer

Z Xie, Y Tian, X Guo, N Xie - Cellular Oncology, 2024 - Springer
Coactivator-associated arginine methyltransferase 1 (CARM1), pivotal for catalyzing
arginine methylation of histone and non-histone proteins, plays a crucial role in developing …

Unraveling the complexity of histone-arginine methyltransferase CARM1 in cancer: from underlying mechanisms to targeted therapeutics

W Jin, J Zhang, X Chen, S Yin, H Yu, F Gao… - Biochimica et Biophysica …, 2023 - Elsevier
Coactivator-associated arginine methyltransferase 1 (CARM1), a type I protein arginine
methyltransferase (PRMT), has been widely reported to catalyze arginine methylation of …

The oncogenic role and immune infiltration for CARM1 identified by pancancer analysis

K Liu, J Ma, J Ao, L Mu, Y Wang, Y Qian… - Journal of …, 2021 - Wiley Online Library
Chromatin‐modifying enzymes, especially protein arginine methyltransferases (PRMTs),
have been identified as candidate targets for cancer. Cellular or animal‐based evidence has …

CARM1/PRMT4: making its mark beyond its function as a transcriptional coactivator

S Suresh, S Huard, T Dubois - Trends in cell biology, 2021 - cell.com
Coactivator-associated arginine methyltransferase 1 (CARM1), identified 20 years ago as a
coregulator of transcription, is an enzyme that catalyzes arginine methylation of proteins …

Differential CARM1 isoform expression in subcellular compartments and among malignant and benign breast tumors

D Shlensky, JA Mirrielees, Z Zhao, L Wang, A Mahajan… - Plos one, 2015 - journals.plos.org
Purpose Coactivator-associated arginine methyltransferase 1 (CARM1) is a coactivator for
ERα and cancer-relevant transcription factors, and can methylate diverse cellular targets …

Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition

E Shishkova, H Zeng, F Liu, NW Kwiecien… - Nature …, 2017 - nature.com
Protein arginine methyltransferases (PRMTs) introduce arginine methylation, a post-
translational modification with the increasingly eminent role in normal physiology and …

[HTML][HTML] A hypermethylation strategy utilized by enhancer-bound CARM1 to promote estrogen receptor α-dependent transcriptional activation and breast …

B Peng, W Li, J Ding, Y He, T Ran, B Xie, Z Wang… - Theranostics, 2020 - ncbi.nlm.nih.gov
While protein arginine methyltransferases (PRMTs) and PRMT-catalyzed protein
methylation have been well-known to be involved in a myriad of biological processes, their …

Protein arginine methyltransferase CARM1 in human breast cancer

M Bacabac, P Liu, W Xu - Endocrinology, 2024 - academic.oup.com
Coactivator-associated arginine methyltransferase 1 (CARM1) is a protein arginine
methyltransferase that deposits asymmetrical dimethylation marks on both histone and non …

CARM1 arginine methyltransferase as a therapeutic target for cancer

M Santos, JW Hwang, MT Bedford - Journal of Biological Chemistry, 2023 - ASBMB
Coactivator-associated arginine methyltransferase 1 (CARM1) is an arginine
methyltransferase that posttranslationally modifies proteins that regulate multiple levels of …