Unconjugated bilirubin, the end product of heme catabolism and antioxidant, induced brain
damage in human neonates is a well-recognized clinical syndrome. However, the cellular …

Encephalopathy induced by hyperbilirubinemia in infants has been described in the medical
literature for over a century but neither the cellular nor molecular mechanisms underlying …

Brain damage induced by unconjugated bilirubin, the end product of heme catabolism, in
human neonates is a well recognized clinical syndrome. However, the cellular and …

High levels of unconjugated bilirubin (UCB) can be neurotoxic. Nevertheless, the
mechanism of UCB interaction with neural cells is still unknown. This study investigates …

The mechanisms of neurotoxicity induced by unconjugated bilirubin (UCB) in newborns are
incompletely understood. UCB may cause both necrotic and apoptotic neuronal death. We …

Background Bilirubin-induced neurological dysfunction (BIND), a severe complication of
extreme neonatal hyperbilirubinemia, could develop into permanent neurodevelopmental …

Research on the mechanisms of bilirubin-induced neurological dysfunction focuses mainly
on neuronal death, astrocyte-mediated events and microglia activation. Although myelin …

High levels of unconjugated bilirubin can be neurotoxic and gliotoxic. However, the effect of
bilirubin on oligodendrocyte viability has never been investigated. In the present study, we …

Hippocampus is one of the brain regions most vulnerable to unconjugated bilirubin (UCB)
encephalopathy, although cerebellum also shows selective yellow staining in kernicterus …

Background Severe hyperbilirubinemia is toxic during central nervous system development.
Prolonged and uncontrolled high levels of unconjugated bilirubin lead to bilirubin-induced …