[HTML][HTML] Gene set enrichment analysis indicates convergence in the mTOR signalling pathway between syndromic and non-syndromic autism

VGO Evangelho, ML Bello, HC Castro… - Neuroscience …, 2023 - Elsevier
Autism is a developmental disorder that affects around 62.1 million people globally.
Estimates of its prevalence have been on the rise. Recent research suggests that in the …

Network-based integrative analysis of genomics, epigenomics and transcriptomics in autism spectrum disorders

N Di Nanni, M Bersanelli, FA Cupaioli… - International journal of …, 2019 - mdpi.com
Current studies suggest that autism spectrum disorders (ASDs) may be caused by many
genetic factors. In fact, collectively considering multiple studies aimed at characterizing the …

Disruption of mTOR and MAPK pathways correlates with severity in idiopathic autism

R Eleonora, B Battan, S Martina, F Hollis… - Translational …, 2019 - search.proquest.com
The molecular signature underlying autism spectrum disorder remains largely unknown.
This study identifies differential expression of mTOR and MAPK pathways in patients …

Disruption of mTOR and MAPK pathways correlates with severity in idiopathic autism

E Rosina, B Battan, M Siracusano, L Di Criscio… - Translational …, 2019 - nature.com
The molecular signature underlying autism spectrum disorder remains largely unknown.
This study identifies differential expression of mTOR and MAPK pathways in patients …

Meta-analysis of whole-transcriptome data for prediction of novel genes associated with autism spectrum disorder

DH Le, NT Van - Proceedings of the 8th International Conference on …, 2017 - dl.acm.org
Autism spectrum disorder (ASD) is a common heterogeneous neurodevelopmental disorder
with typical symptoms such as impaired social interaction, language and communication …

Meta‐analysis of gene expression in autism spectrum disorder

C Ch'ng, W Kwok, S Rogic, P Pavlidis - Autism Research, 2015 - Wiley Online Library
Autism spectrum disorders (ASD) are clinically heterogeneous and biologically complex. In
general it remains unclear, what biological factors lead to changes in the brains of autistic …

Integrated Analysis and Identification of Genetic Risk Alleles Related to Autism Spectrum Disorder

Y Wu, P Wang - 2023 11th International Conference on …, 2023 - ieeexplore.ieee.org
Autism spectrum disorder (ASD) is a range of conditions, including difficulties in cognition,
social interaction, communication, and repetitive motion. To understand the mechanism of …

Unveiling promising drug targets for autism spectrum disorder: insights from genetics, transcriptomics, and proteomics

R Jiang, W Huang, X Qiu, J Chen, R Luo… - Briefings in …, 2024 - academic.oup.com
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder for which
current treatments are limited and drug development costs are prohibitive. Identifying drug …

Dysfunctional mTORC1 signaling: a convergent mechanism between syndromic and nonsyndromic forms of autism spectrum disorder?

J Magdalon, SM Sánchez-Sánchez… - International Journal of …, 2017 - mdpi.com
Whereas autism spectrum disorder (ASD) exhibits striking heterogeneity in genetics and
clinical presentation, dysfunction of mechanistic target of rapamycin complex 1 (mTORC1) …

Abnormal mTOR Signaling Pathway Activity in Autism Spectrum Disorders: Prospects of Mechanism-Based Therapy

EA Trifonova, AA Kotliarova, AV Kochetov - Molecular Biology, 2023 - Springer
Autism spectrum disorder (ASD) is a developmental disorder characterized by the early
onset of problems with communication, learning, and behavior. The syndromic form of ASD …