Preconditioning and Engineering Strategies for Improving the Efficacy of Mesenchymal Stem Cell‐Derived Exosomes in Cell‐Free Therapy

S Chen, F Sun, H Qian, W Xu, J Jiang - Stem cells international, 2022 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been widely applied to regenerative medicine owing
to their multiple differentiation, self‐renewal, and immunomodulatory abilities. Exosomes are …

Challenges and strategies: Scalable and efficient production of mesenchymal stem cells-derived exosomes for cell-free therapy

W Pan, H Chen, A Wang, F Wang, X Zhang - Life sciences, 2023 - Elsevier
Exosomes are small membrane vesicles secreted by most cell types, and widely exist in cell
supernatants and various body fluids. They can transmit numerous bioactive elements, such …

Engineering mesenchymal stem cells to improve their exosome efficacy and yield for cell-free therapy

J Phan, P Kumar, D Hao, K Gao… - Journal of extracellular …, 2018 - Taylor & Francis
Through traditional medicine, there were diseases and disorders that previously remained
untreated or were simply thought to be incurable. Since the discovery of mesenchymal stem …

[HTML][HTML] Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine

ZJ Ma, JJ Yang, YB Lu, ZY Liu… - World journal of stem …, 2020 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) are multipotent stem cells with marked potential for
regenerative medicine because of their strong immunosuppressive and regenerative …

Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials

A Lotfy, NM AboQuella, H Wang - Stem Cell Research & Therapy, 2023 - Springer
Mesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their
robust immunomodulatory and regenerative properties. Their paracrine activity is one of the …

Mesenchymal stem cell-derived exosomes for clinical use

M Mendt, K Rezvani, E Shpall - Bone marrow transplantation, 2019 - nature.com
Mesenchymal stem/stromal cells (MSCs) are commonly used as a source of cellular therapy
due to their strong immunosuppressive and regenerative effects. One of the key …

Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine

S Nikfarjam, J Rezaie, NM Zolbanin, R Jafari - Journal of translational …, 2020 - Springer
Mesenchymal stem cells (MSCs) have captured great attention in regenerative medicine for
over a few decades by virtue of their differentiation capacity, potent immunomodulatory …

Therapeutic features and updated clinical trials of mesenchymal stem cell (MSC)-derived exosomes

BC Lee, I Kang, KR Yu - Journal of clinical medicine, 2021 - mdpi.com
Identification of the immunomodulatory and regenerative properties of mesenchymal stem
cells (MSCs) have made them an attractive alternative therapeutic option for diseases with …

New therapeutic approaches of mesenchymal stem cells-derived exosomes

J Janockova, L Slovinska, D Harvanova… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem cells (MSCs) have been demonstrated to have a great potential in the
treatment of several diseases due to their differentiation and immunomodulatory capabilities …

Preclinical translation of exosomes derived from mesenchymal stem/stromal cells

FM Elahi, DG Farwell, JA Nolta, JD Anderson - Stem cells, 2020 - academic.oup.com
Exosomes are nanovesicles secreted by virtually all cells. Exosomes mediate the horizontal
transfer of various macromolecules previously believed to be cell-autonomous in nature …