Abnormal zonae pellucidae in mice lacking ZP1 result in early embryonic loss

T Rankin, P Talbot, E Lee, J Dean - Development, 1999 - journals.biologists.com
All vertebrates have an egg shell that surrounds ovulated eggs and plays critical roles in
gamete recognition. This extracellular matrix is known as the zona pellucida in eutherian …

Defective zonae pellucidae in Zp2-null mice disrupt folliculogenesis, fertility and development

TL Rankin, M O'Brien, E Lee, K Wigglesworth… - …, 2001 - journals.biologists.com
All vertebrate eggs are surrounded by an extracellular matrix. This matrix is known as the
zona pellucida in mammals and is critically important for the survival of growing oocytes …

Human ZP3 restores fertility in Zp3 null mice without affecting order-specific sperm binding

TL Rankin, ZB Tong, PE Castle, E Lee… - …, 1998 - journals.biologists.com
The mammalian zona pellucida surrounding ovulated eggs mediates sperm binding at
fertilization, provides a postfertilization block to polyspermy, and facilitates passage of pre …

Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile

T Rankin, M Familari, E Lee, A Ginsberg… - …, 1996 - journals.biologists.com
Mammalian oocytes synthesize and secrete a zona pellucida that surrounds the growing
oocytes, ovulated eggs and preimplantation embryos. The extracellular zona matrix is …

Human sperm bind to the N-terminal domain of ZP2 in humanized zonae pellucidae in transgenic mice

B Baibakov, NA Boggs, B Yauger, G Baibakov… - Journal of Cell …, 2012 - rupress.org
Fertilization requires taxon-specific gamete recognition, and human sperm do not bind to
zonae pellucidae (ZP1–3) surrounding mouse eggs. Using transgenesis to replace …

The mouse egg's zona pellucida

PM Wassarman, ES Litscher - Current topics in developmental biology, 2018 - Elsevier
All mammalian eggs are surrounded by a highly specialized extracellular matrix (ECM),
called the zona pellucida (ZP), that functions before, during, and after fertilization. Unlike …

A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans

MA Avella, B Baibakov, J Dean - Journal of Cell Biology, 2014 - rupress.org
The extracellular zona pellucida surrounds ovulated eggs and mediates gamete recognition
that is essential for mammalian fertilization. Zonae matrices contain three (mouse) or four …

New insights into the mammalian egg zona pellucida

C Moros-Nicolás, P Chevret… - International Journal of …, 2021 - mdpi.com
Mammalian oocytes are surrounded by an extracellular coat called the zona pellucida (ZP),
which, from an evolutionary point of view, is the most ancient of the coats that envelope …

The zona pellucida: using molecular genetics to study the mammalian egg coat

T Rankin, J Dean - Reviews of Reproduction, 2000 - rep.bioscientifica.com
An extracellular matrix that mediates critical steps in fertilization and early development
surrounds all vertebrate eggs. In mice and humans, this matrix is known as the zona …

Zona pellucida genes and proteins: essential players in mammalian oogenesis and fertility

PM Wassarman, ES Litscher - Genes, 2021 - mdpi.com
All mammalian oocytes and eggs are surrounded by a relatively thick extracellular matrix
(ECM), the zona pellucida (ZP), that plays vital roles during oogenesis, fertilization, and …