The “Obesity Paradox” and the use of NOAC

R Bottino, A Carbone, B Liccardo, P Golino… - … : From Pharmacology to …, 2021 - Springer
Obesity is a worldwide health problem at increasing incidence associated with high
morbidity and mortality. Although obesity increases patients' cardiovascular (CV) risk, more …

[HTML][HTML] Obesity paradox in atrial fibrillation and its relation with the new oral anticoagulants

AIN Lima Filho, MC do Rego Barros… - Current Cardiology …, 2022 - ncbi.nlm.nih.gov
Obesity, a chronic disease established as a global epidemic by the World Health
Organization, is considered a risk factor for atrial fibrillation (AF), the most common …

Oral anticoagulant use in patients with morbid obesity: a systematic review and meta-analysis

TF Wang, M Carrier, K Fournier… - Thrombosis and …, 2022 - thieme-connect.com
Objectives Obesity is associated with increased risks of atrial fibrillation (AF) and venous
thromboembolism (VTE) for which anticoagulation is commonly used. However, data on the …

[HTML][HTML] Direct oral anticoagulation and severe obesity–One size fits all?

AC Fender, M Gawalko, D Dobrev - International Journal of …, 2021 - ncbi.nlm.nih.gov
Oral anticoagulation is obligatory in patients with atrial fibrillation (AF) to prevent
thromboembolic stroke. Direct direct oral anticoagulants (DOAC) exhibit improved safety …

Nonvitamin K Antagonist Oral Anticoagulants in Patients with Extreme Body Weights: One Size Fits All?

SR Lee, EK Choi - Thrombosis and Haemostasis, 2021 - thieme-connect.com
Although nonvitamin K antagonist oral anticoagulants (NOACs) have generally shown
comparable efficacy and better safety compared with warfarin, atrial fibrillation (AF) patients …

Obesity paradox in atrial fibrillation: implications for outcomes and relationship with oral anticoagulant drugs

M Proietti, G Boriani - American Journal of Cardiovascular Drugs, 2020 - Springer
In the last 40 years, concern about the obesity epidemic has increased. Data from the
current literature highlight a strong relationship between obesity and atrial fibrillation (AF) …

Clinical performance of nonvitamin K antagonist oral anticoagulants in real-world obese patients with atrial fibrillation

V Russo, R Bottino, A Rago, AA Papa… - … in Thrombosis and …, 2020 - thieme-connect.com
The prevalence of both atrial fibrillation (AF) and obesity has steadily increased. Nonvitamin
K antagonist oral anticoagulants (NOACs) have been shown to be more effective and safer …

Comparative Safety and Efficacy of Rivaroxaban, Dabigatran and Apixaban in Obese and Morbidly Obese Patients With Heart Failure and Non-Valvular Atrial …

Y Chugh, HB Krishna, RQ Ayala, I Zepeda, D Li… - Circulation, 2018 - Am Heart Assoc
Introduction: Obese and morbidly obese patients are under-represented in clinical trials of
non-vitamin K oral anticoagulants (NOAC). Patients with atrial fibrillation (AF) and …

The safety and efficacy of nonvitamin K antagonist oral anticoagulants in morbidly obese patients with atrial fibrillation: a meta-analysis

S Elfar, SA Mahmoud, S Hamdi, AA Emad… - BMC Cardiovascular …, 2024 - Springer
Background and aim Atrial fibrillation (AF) is the most frequently observed cardiac
arrhythmia in clinical settings. Obesity can influence the efficacy of the treatment …

DOACs or warfarin use in morbidly obese patients (BMI> 40 kg/m2) on anticoagulant therapy?: a systematic review and meta-analysis

M Sagris, N Ktenopoulos, K Pamporis… - European Heart …, 2023 - academic.oup.com
Introduction Current guidelines and consensus statements have advised against the use of
direct oral anticoagulants (DOACs) for morbidly obese patients (BMI> 40 kg/m2), indicating …