The present study used behavioral analyses to investigate the involvement of the
NO/cGMP/K ATP pathway, serotoninergic, and opioid systems in the antinociceptive action …

cis-Dioxolane (0.5–2 μg), a muscarinic receptor agonist, given intracerebroventricularly (icv)
produced a dose-dependent inhibition of the tail-flick response in male ICR mice.(+)-cis …

Background Several lines of evidence have indicated that nitric oxide (NO) plays complex
and diverse roles in modulation of pain/analgesia. However, the roles of charged and …

The present study investigated the analgesic effect of a novel synthetic cyclohexanone
derivative, 2, 6-bis-4-(hydroxyl-3-methoxybenzilidine)-cyclohexanone or BHMC in a mouse …

In view of the scarce information about the analgesic mechanism of κ-opioid receptor
agonists, the objective of the present study was to determine whether nitric oxide (NO) is …

The pyrazol compounds are known to possess antipyretic, analgesic and anti-inflammatory
activities. This study was conducted to investigate the peripheral antinociceptive effect of the …

Crotalphine, a 14 amino acid peptide first isolated from the venom of the South American
rattlesnake Crotalus durissus terrificus, induces a peripheral long-lasting and opioid …

The aim of this study was to examine if the peripheral antinociceptive effects of the opioid
agonist/antagonist nalbuphine and buprenorphine involve the sequential participation of …

There is evidence that local peripheral administration of morphine produces antinociception
through the activation of the nitric oxide (NO)-cyclic GMP-K+ channels pathway. Therefore …

Commonly used pain therapeutics, such as opioid medications, exert dangerous side effects
and lack effectiveness in treating some types of pain. Ketamine is also used to treat pain, but …