Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

It is now well established that the mammalian brain has the capacity to produce new
neurons into adulthood. One such region that provides the proper milieu to sustain …

Psychiatric and neurologic disorders take an enormous toll on society. Alleviating the
devastating symptoms and consequences of neuropsychiatric disorders such as addiction …

Adult hippocampal neurogenesis is the process by which new functional neurons are added
to the adult dentate gyrus of the hippocampus. Animal studies have shown that the degree of …

The demographic changes in the foreseeable future stress the need for research on
successful cognitive aging. Advancing age constitutes a primary risk factor for disease of the …

The capability of the mammalian brain to generate new neurons through the lifespan has
gained much attention for the promise of new therapeutic possibilities especially for the …

The formation of new neurons in the adult central nervous system (CNS) has been
recognized as one of the major findings in neuroanatomical research. The hippocampal …

Adult neurogenesis, the process of generating new neurons from neural stem cells, plays
significant roles in synaptic plasticity, memory, and mood regulation. In the mammalian …

Failing adult hippocampal neurogenesis may not explain major depression, addiction or
schizophrenia, but contributes to the hippocampal aspects of the disease. We propose that …

Accumulating evidence implicates hippocampal neurogenesis in the pathophysiology of
depression. Psychosocial stress reduces neurogenesis in rodents, whereas chronic …