[HTML][HTML] Mesenchymal stem cell-derived exosomes as delivery vehicles for non-coding RNAs in lung diseases

Y Feng, K Guo, J Jiang, S Lin - Biomedicine & Pharmacotherapy, 2024 - Elsevier
The burden of lung diseases is gradually increasing with an increase in the average human
life expectancy. Therefore, it is necessary to identify effective methods to treat lung diseases …

Molecular insight into the therapeutic effects of stem cell-derived exosomes in respiratory diseases and the potential for pulmonary delivery

MH Azhdari, N Goodarzi, M Doroudian… - International Journal of …, 2022 - mdpi.com
Respiratory diseases are the cause of millions of deaths annually around the world. Despite
the recent growth of our understanding of underlying mechanisms contributing to the …

Emerging therapeutic potential of mesenchymal stem cell-derived extracellular vesicles in chronic respiratory diseases: an overview of recent progress

Y Ma, X Liu, Y Long, Y Chen - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are able to carry genetic
and protein goods to mediate the interaction between MSCs and target cells. Recently, more …

Therapeutic application of mesenchymal stem cells derived exosomes in neurodegenerative diseases: a focus on non-coding RNAs cargo, drug delivery potential …

M Hedayat, M Ahmadi, M Shoaran, J Rezaie - Life Sciences, 2023 - Elsevier
Despite the massive efforts advanced over recent years in emerging therapies for
neurodegenerative diseases, effective treatment for these diseases is still an urgent need …

Exosomal lncRNA TCONS_00064356 derived from injured alveolar epithelial type II cells affects the biological characteristics of mesenchymal stem cells

L Song, J Peng, X Guo - Life Sciences, 2021 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disease, and a
leading cause of morbidity and mortality worldwide. There is still a lack of effective treatment …

Advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatment

Z Zhai, T Cui, J Chen, X Mao, T Zhang - Journal of Translational Medicine, 2023 - Springer
Chronic lung diseases include an array of conditions that impact airways and lung
structures, leading to considerable societal burdens. Mesenchymal stem cells (MSCs) and …

Clinical application of mesenchymal stem cell-derived extracellular vesicle-based therapeutics for inflammatory lung diseases

Y Fujita, T Kadota, J Araya, T Ochiya… - Journal of Clinical …, 2018 - mdpi.com
It is currently thought that extracellular vesicles (EVs), such as exosomes and microvesicles,
play an important autocrine/paracrine role in intercellular communication. EVs package …

Therapeutic role of mesenchymal stem cell-derived exosomes in respiratory disease

MJ Zargar, S Kaviani, M Vasei… - Stem Cell Research & …, 2022 - Springer
Exosomes are extracellular vesicles found in various tissues, blood circulation, and tissue
fluids, secreted into the extracellular environment by fusing a multivesicular body with a …

The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases

E Oveili, S Vafaei, H Bazavar, Y Eslami… - Cell Communication and …, 2023 - Springer
MicroRNAs (miRNAs) are a group of small non-coding RNAs that regulate gene expression
by targeting mRNA. Moreover, it has been shown that miRNAs expression are changed in …

Exosome-mediated small RNA delivery: a novel therapeutic approach for inflammatory lung responses

D Zhang, H Lee, X Wang, A Rai, M Groot, Y Jin - Molecular Therapy, 2018 - cell.com
Exosomes (EXOs) are a type of extracellular nanovesicles released from living cells.
Accumulating evidence suggests that EXOs are involved in the pathogenesis of human …