Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis

J Kaur, R Adya, BK Tan, J Chen… - … and biophysical research …, 2010 - Elsevier
Chemerin acting via its distinct G protein-coupled receptor CMKLR1 (ChemR23), is a novel
adipokine, circulating levels of which are raised in inflammatory states. Chemerin shows …

Chemerin promotes angiogenesis in vivo

N Nakamura, K Naruse, Y Kobayashi… - Physiological …, 2018 - Wiley Online Library
Chemerin acts as a chemotactic factor for leukocyte populations expressing the G protein‐
coupled receptor CMKLR 1 (ChemR23). It is also an adipocytokine involved in obesity and …

[HTML][HTML] Chemerin and CMKLR1 expression in human arteries and periadventitial fat: a possible role for local chemerin in atherosclerosis?

CG Kostopoulos, SG Spiroglou, JN Varakis… - BMC Cardiovascular …, 2014 - Springer
Background Depending on their anatomical location, different fat depots have a different
capacity to produce bioactive peptides, called adipokines. Adipokines produced by …

Chemerin regulates crosstalk between adipocytes and vascular cells through Nox

KB Neves, A Nguyen Dinh Cat, RAM Lopes, FJ Rios… - …, 2015 - Am Heart Assoc
Adipocytes produce adipokines, including chemerin, a chemoattractant that mediates effects
through its ChemR23 receptor. Chemerin has been linked to endothelial dysfunction and …

Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism

B Bondue, V Wittamer, M Parmentier - Cytokine & growth factor reviews, 2011 - Elsevier
Chemerin was isolated as the natural ligand of the G protein-coupled receptor ChemR23.
Chemerin acts as a chemotactic factor for leukocyte populations expressing ChemR23 …

Chemerin connects fat to arterial contraction

SW Watts, AM Dorrance, ME Penfold… - … , and vascular biology, 2013 - Am Heart Assoc
Objective—Obesity and hypertension are comorbid in epidemic proportion, yet their
biological connection is largely a mystery. The peptide chemerin is a candidate for …

Chemerin promotes the proliferation and migration of vascular smooth muscle and increases mouse blood pressure

H Kunimoto, K Kazama, M Takai… - American Journal …, 2015 - journals.physiology.org
Blood chemerin concentration shows positive correlation not only with body mass index and
serum triglyceride level but also with systolic blood pressure. While it seems likely that …

[HTML][HTML] Role of Chemerin/ChemR23 axis as an emerging therapeutic perspective on obesity-related vascular dysfunction

Y Xie, L Liu - Journal of translational medicine, 2022 - Springer
Sufficient epidemiological investigations demonstrate that there is a close correlation
between obesity and vascular dysfunction. Nevertheless, specific mechanisms underlying …

Chemerin Elicits Potent Constrictor Actions via Chemokine‐Like Receptor 1 (CMKLR 1), not G‐Protein‐Coupled Receptor 1 (GPR 1), in Human and Rat Vasculature

AJ Kennedy, P Yang, C Read, RE Kuc… - Journal of the …, 2016 - Am Heart Assoc
Background Circulating levels of chemerin are significantly higher in hypertensive patients
and positively correlate with blood pressure. Chemerin activates chemokine‐like receptor 1 …

Chemerin is associated with markers of inflammation and components of the metabolic syndrome but does not predict coronary atherosclerosis

M Lehrke, A Becker, M Greif, R Stark… - European journal of …, 2009 - academic.oup.com
Objectives Chemerin is a recently discovered adipokine that regulates adipocyte
differentiation and modulates chemotaxis and activation of dendritic cells and macrophages …