Maintaining proper mRNA levels is a key aspect in the regulation of gene expression. The
balance between mRNA synthesis and decay determines these levels. We demonstrate that …

The process of mRNA decay is integral to the post-transcriptional control of gene
expression. The enzymes of the pathway have been identified, and now several laboratories …

The steady-state levels of mRNAs depend upon their combined rates of synthesis and
processing, transport from the nucleus to cytoplasm, and decay in the cytoplasm. In …

The decay of several yeast mRNAs occurs by a mechanism in which deadenylation
precedes decapping and subsequent 5′-to-3′ exonucleolytic decay. In order to identify …

To determine pathways of mRNA turnover in yeast, we have followed the poly (A) tail
removal and degradation of a pulse of newly synthesized transcripts from four different …

When considering the control of gene expression, the focus has traditionally been on
transcriptional regulation. Recently, however, the large contribution made by mRNA decay …

While the potential importance of mRNA stability to the regulation of gene expression has
been recognized, the structures and mechanisms involved in the determination of individual …

The level of an MRNA in the cytoplasm represents a balance between the rate at which the
mRNA precursor is synthesized in the nucleus and the rates of nuclear RNA processing and …

Discoveries made over the past 20 years highlight the importance of mRNA decay as a
means of modulating gene expression and thereby protein production. Up until recently …

Promoters are DNA elements that enable transcription and its regulation by trans-acting
factors. Here, we demonstrate that yeast promoters can also regulate mRNA decay after the …