INTRODUCTION: The objective of this study was to evaluate the short-term effects of
clodronate, a first-generation bisphosphonate, on early alveolar bone remodeling and root …

Clodronate, a non-N-containing bisphosphonate, strongly inhibits bone resorption and also
has anti-inflammatory properties. The purpose of this study was to examine the effect of the …

INTRODUCTION: Osteoclastic activity is required for orthodontic force to move teeth through
alveolar bone. Bisphosphonates are drugs that inhibit osteoclast maturation, function, and …

This study was designed to clarify the effects of systemic administration of bisphosphonate,
pamidronate, on the bone resorbing activity of osteoclasts during relapse of rat molars, after …

Introduction The aim of this pilot study was to investigate the effect of long-term
bisphosphonate drug use (bone burden) on orthodontic tooth movement in a rat model …

Orthodontic tooth movement is the result of bone remodeling that occurs in periodontal
ligament and alveolar bone tissue as a response to mechanical loading of the tooth. The aim …

Mechanical stress such as orthodontic tooth movement induces osteoclastogenesis.
Sometimes, excessive mechanical stress results in root resorption during orthodontic tooth …

Increases in bone strains above a certain threshold have a positive effect on bone mass,
whereas reductions in strain magnitude lead to bone loss and osteopenia; the term …

The aim of the present study was to investigate the effect of the local administration of three
kinds of bisphosphonates–etidronate, alendronate, and pamidronate–on orthodontic root …

Root resorption associated with tooth movement is an unsolved problem in orthodontics. If
such root resorption could be prevented, it would be an important contribution toward …