Boronic acid compounds have been used, because of their unique structural features, for the
development of potent enzyme inhibitors, boron neutron capture agents for cancer therapy …

In 2003, bortezomib, a first-in-class therapeutic, gained approval from the US Federal Drug
Administration for the treatment of relapsed multiple myeloma and mantle cell lymphoma …

Research related to boronic acids, from synthetic development to materials to drug
discovery, has skyrocketed in the past 20 years. In terms of drug discovery, the incorporation …

Boron containing compounds have not been widely studied in Medicinal Chemistry, mainly
due to the idea that this group could confer some toxicity. Nowadays, this concept has been …

Structurally, boronic acids are trivalent boron-containing organic compounds that possess
one alkyl substituent (ie, a C–B bond) and two hydroxyl groups to fill the remaining valences …

The use of boron in small-molecule pharmaceuticals is increasing. Boron's ubiquitous
occurrence in nature and the recent success of a boronic acid drug (Velcade®) in the clinic …

Boron was misconstrued as a toxic element for animals, which retarded the growth of boron-
containing drug discovery in the last century. Nevertheless, modern applications of boronic …

Although boronic acids have attracted considerable interest as versatile intermediates in
organic synthesis, their contributions in chemical biology and drug discovery programs have …

The present essay offers an overview of the latest developments in the chemistry of
organoboron compounds. The unique structural characteristics and the versatile reactivity …

Advances in the field of boron chemistry have expanded the application of this element in
Medicinal Chemistry. Boron-containing compounds represent a new class for medicinal …