Thalamic atrophy in multiple sclerosis: a magnetic resonance imaging marker of neurodegeneration throughout disease

CJ Azevedo, SY Cen, S Khadka, S Liu… - Annals of …, 2018 - Wiley Online Library
Objective Thalamic volume is a candidate magnetic resonance imaging (MRI)‐based
marker associated with neurodegeneration to hasten development of neuroprotective …

Intrinsic and extrinsic mechanisms of thalamic pathology in multiple sclerosis

KR Mahajan, K Nakamura, JA Cohen… - Annals of …, 2020 - Wiley Online Library
Objective Thalamic atrophy is among the earliest brain changes detected in patients with
multiple sclerosis (MS) and the degree of thalamic atrophy is a strong predictor of disability …

Thalamic atrophy and cognition in multiple sclerosis

MK Houtchens, RHB Benedict, R Killiany, J Sharma… - Neurology, 2007 - AAN Enterprises
Objectives: Recent studies have indicated that brain atrophy is more closely associated with
cognitive impairment in multiple sclerosis (MS) than are conventional MRI lesion measures …

Thalamic damage and long-term progression of disability in multiple sclerosis

MA Rocca, S Mesaros, E Pagani, MP Sormani, G Comi… - Radiology, 2010 - pubs.rsna.org
Purpose To estimate the relative contributions of baseline thalamic atrophy and
abnormalities shown at magnetization transfer (MT) magnetic resonance (MR) imaging, as …

Thalamic injury and cognition in multiple sclerosis

M Amin, D Ontaneda - Frontiers in Neurology, 2021 - frontiersin.org
Multiple sclerosis (MS) produces demyelination and degeneration in both gray and white
matter. Both cortical and deep gray matter injury is observed during the course of MS …

Clinical significance of atrophy and white matter mean diffusivity within the thalamus of multiple sclerosis patients

RHB Benedict, HE Hulst, N Bergsland… - Multiple Sclerosis …, 2013 - journals.sagepub.com
Background: Gray-matter (GM) atrophy is strongly predictive of cognitive impairment in
multiple sclerosis (MS) patients. The thalamus is the region where the atrophy/cognition …

Clinical relevance of brain atrophy assessment in multiple sclerosis. Implications for its use in a clinical routine

R Zivadinov, D Jakimovski, S Gandhi… - Expert review of …, 2016 - Taylor & Francis
Introduction: Brain atrophy measurement in multiple sclerosis (MS) has become an
important outcome for determining patients at risk for developing physical and cognitive …

Localized atrophy of the thalamus and slowed cognitive processing speed in MS patients

N Bergsland, R Zivadinov, MG Dwyer… - Multiple Sclerosis …, 2016 - journals.sagepub.com
Background: Deep gray matter (DGM) atrophy is common in multiple sclerosis (MS), but no
studies have investigated surface-based structure changes over time with respect to healthy …

Volume loss in the deep gray matter and thalamic subnuclei: a longitudinal study on disability progression in multiple sclerosis

S Magon, C Tsagkas, L Gaetano, R Patel… - Journal of …, 2020 - Springer
Background Volume loss in the deep gray matter (DGM) has been reported in patients with
multiple sclerosis (MS) already at early stages of the disease and is thought to progress …

Thalamic atrophy is associated with development of clinically definite multiple sclerosis

R Zivadinov, E Havrdová, N Bergsland, M Tyblova… - Radiology, 2013 - pubs.rsna.org
Purpose To investigate the association between the development of thalamic and cortical
atrophy and the conversion to clinically definite multiple sclerosis (CDMS) in patients with …