Alterations of the microRNA network cause neurodegenerative disease

SS Hébert, B De Strooper - Trends in neurosciences, 2009 - cell.com
Brain development crucially depends on the integrity of microRNA (miRNA) pathways, which
function at the post-transcriptional level as a rheostat of the transcriptome and proteome of …

MicroRNAs in neurodegeneration

N Bushati, SM Cohen - Current opinion in neurobiology, 2008 - Elsevier
microRNAs (miRNAs) act as post-transcriptional regulators of gene expression in diverse
cellular and developmental processes. Many miRNAs are expressed specifically in the …

MicroRNAs and deregulated gene expression networks in neurodegeneration

KC Sonntag - Brain research, 2010 - Elsevier
Neurodegeneration is characterized by the progressive loss of neuronal cell types in the
nervous system. Although the main cause of cell dysfunction and death in many …

microRNAs and neurodegenerative diseases

L Qiu, EK Tan, L Zeng - … : Medical Evidence: From Molecular Biology to …, 2015 - Springer
Abstract microRNAs (miRNAs) are small, noncoding RNA molecules that through imperfect
base-pairing with complementary sequences of target mRNA molecules, typically cleave …

Causes and consequences of microRNA dysregulation in neurodegenerative diseases

L Tan, JT Yu, L Tan - Molecular neurobiology, 2015 - Springer
Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), originate from a loss of …

MicroRNAs (miRNAs) in neurodegenerative diseases

PT Nelson, WX Wang, BW Rajeev - Brain pathology, 2008 - Wiley Online Library
Aging‐related neurodegenerative diseases (NDs) are the culmination of many different
genetic and environmental influences. Prior studies have shown that RNAs are …

MicroRNAs in neurodegenerative diseases and their therapeutic potential

E Junn, MM Mouradian - Pharmacology & therapeutics, 2012 - Elsevier
MicroRNAs (miRNAs) are abundant, endogenous, short, noncoding RNAs that act as
important post-transcriptional regulators of gene expression by base-pairing with their target …

miRNAs: key players in neurodegenerative disorders and epilepsy

HK Karnati, MK Panigrahi, RK Gutti… - Journal of …, 2015 - content.iospress.com
MicroRNAs (miRNAs) are endogenous,∼ 22 nucleotide, non-coding RNA molecules that
function as post-transcriptional regulators of gene expression. miRNA dysregulation has …

MicroRNA function in neuronal development, plasticity and disease

R Fiore, G Siegel, G Schratt - Biochimica et Biophysica Acta (BBA)-Gene …, 2008 - Elsevier
The development and function of the nervous system is orchestrated by a plethora of gene
regulatory mechanisms. MicroRNAs (miRNAs), an abundant class of small non-coding …

MicroRNA: implications for Alzheimer disease and other human CNS disorders

OC Maes, HM Chertkow, E Wang… - Current …, 2009 - ingentaconnect.com
Understanding complex diseases such as sporadic Alzheimer disease (AD) has been a
major challenge. Unlike the familial forms of AD, the genetic and environmental risks factors …