[HTML][HTML] Recent progress on FAK inhibitors with dual targeting capabilities for cancer treatment
X Wu, J Wang, Q Liang, R Tong, J Huang… - Biomedicine & …, 2022 - Elsevier
Focal adhesion kinase (FAK, also known as PTK2) is a tyrosine kinase that regulates
integrin and growth factor signaling pathways and is involved in the migration, proliferation …
integrin and growth factor signaling pathways and is involved in the migration, proliferation …
FAK-targeted and combination therapies for the treatment of cancer: an overview of phase I and II clinical trials
A Mohanty, RR Pharaon, A Nam, S Salgia… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: Focal adhesion kinase (FAK) is a promising target for the treatment of solid
tumors because its expression has been linked to tumor progression, invasion, and drug …
tumors because its expression has been linked to tumor progression, invasion, and drug …
FAK inhibitors in Cancer, a patent review
PC Lv, AQ Jiang, WM Zhang, HL Zhu - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that localizes at
sites of cell adhesion to the extracellular matrix (ECM) and mediates signalling events …
sites of cell adhesion to the extracellular matrix (ECM) and mediates signalling events …
[HTML][HTML] Focal adhesion kinase inhibitors, a heavy punch to cancer
Y Wu, N Li, C Ye, X Jiang, H Luo, B Zhang, Y Zhang… - Discover Oncology, 2021 - Springer
Kinases are the ideal druggable targets for diseases and especially were highlighted on
cancer therapy. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and its …
cancer therapy. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and its …
Targeting FAK in anticancer combination therapies
JC Dawson, A Serrels, DG Stupack… - Nature Reviews …, 2021 - nature.com
Focal adhesion kinase (FAK) is both a non-receptor tyrosine kinase and an adaptor protein
that primarily regulates adhesion signalling and cell migration, but FAK can also promote …
that primarily regulates adhesion signalling and cell migration, but FAK can also promote …
Development of focal adhesion kinase inhibitors in cancer therapy
W Wee Ma - Anti-Cancer Agents in Medicinal Chemistry …, 2011 - ingentaconnect.com
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase implicated in cancer
progression, and plays a vital role in integrating environmental signals from growth factors …
progression, and plays a vital role in integrating environmental signals from growth factors …
[HTML][HTML] Drug discovery targeting focal adhesion kinase (FAK) as a promising cancer therapy
XJ Pang, XJ Liu, Y Liu, WB Liu, YR Li, GX Yu, XY Tian… - Molecules, 2021 - mdpi.com
FAK is a nonreceptor intracellular tyrosine kinase which plays an important biological
function. Many studies have found that FAK is overexpressed in many human cancer cell …
function. Many studies have found that FAK is overexpressed in many human cancer cell …
Evolving therapies and FAK inhibitors for the treatment of cancer
K Bullard Dunn, M Heffler… - Anti-Cancer Agents in …, 2010 - ingentaconnect.com
Despite advances in medical and surgical therapy, cancer kills more than half a million
people in the United States annually, and the majority of these patients succumb to …
people in the United States annually, and the majority of these patients succumb to …
FAK inhibitors as promising anticancer targets: present and future directions
M Mustafa, AA Abd El-Hafeez… - Future medicinal …, 2021 - Taylor & Francis
FAK, a nonreceptor tyrosine kinase, has been recognized as a novel target class for the
development of targeted anticancer agents. Overexpression of FAK is a common occurrence …
development of targeted anticancer agents. Overexpression of FAK is a common occurrence …
Progress in the development of small molecular inhibitors of focal adhesion kinase (FAK)
Y Lu, H Sun - Journal of Medicinal Chemistry, 2020 - ACS Publications
Focal adhesion kinase (FAK) is a nonreceptor intracellular tyrosine kinase that plays an
essential role in cancer cell adhesion, survival, proliferation, and migration through both its …
essential role in cancer cell adhesion, survival, proliferation, and migration through both its …
相关搜索
- fak inhibitors treatment of cancer
- fak inhibitors targeting capabilities
- cancer treatment targeting capabilities
- fak inhibitors evolving therapies
- evolving therapies treatment of cancer
- fak inhibitors therapeutic potential
- therapeutic potential treatment of cancer
- fak inhibitors anticancer targets
- combination therapies treatment of cancer