Chronic liver disease is associated with remarkable alterations in the intra-and extrahepatic
vasculature. Because of these changes, the fields of liver vasculature and portal …

Portal hypertension, defined as increased pressure in the portal vein, develops as a
consequence of increased intrahepatic vascular resistance due to the dysregulation of liver …

Portal hypertension is caused by an increased intrahepatic resistance, a major
consequence of cirrhosis. Endothelial dysfunction in liver sinusoidal endothelial cells …

The liver microcirculatory milieu, mainly composed of liver sinusoidal endothelial cells
(LSECs), hepatic stellate cells (HSCs) and hepatic macrophages, has an essential role in …

Over the past two decades the advances in molecular cell biology have led to significant
discoveries about the pathophysiology of portal hypertension (PHT). In particular, great …

Portal hypertension accounts for the majority of morbidity and mortality that is encountered in
patients with cirrhosis. Portal hypertension is initiated in large part through increases in …

The most frequent cause of portal hypertension is liver cirrhosis, and many of lethal
complications of cirrhosis such as ascites and gastroesophageal variceal hemorrhage are …

Portal hypertension is the main cause of complications in patients with chronic liver disease.
Over the past 25years, progress in the understanding of the pathophysiology of portal …

Cirrhosis is characterized by marked abnormalities in the hepatic circulation. Functionally,
there is an increased vascular tone and impaired flow-mediated vasorelaxation, whereas …

Portal hypertension develops as a result of increased intrahepatic vascular resistance often
caused by chronic liver disease that leads to structural distortion by fibrosis, microvascular …