IgA nephropathy (IgAN), the most prevalent primary glomerulonephritis worldwide, carries a
considerable lifetime risk of kidney failure. Clinical manifestations of IgAN vary from …

Abstract Globally, IgA nephropathy (IgAN) is the most common primary glomerulonephritis
that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but …

Background IgA nephropathy (IgAN), the most common primary glomerulonephritis
worldwide, has serious outcomes with end-stage renal disease developing in 30–50% of …

IgA nephropathy (IgAN) is the most common primary glomerulonephritis in the world among
patients undergoing renal biopsy. Approximately 30% of patients with IgAN develop end …

IgA nephropathy (IgAN), the most common primary glomerular disease worldwide, is
characterized by glomerular deposition of IgA1-containing immune complexes. The IgA1 …

Background: IgA nephropathy, a frequent cause of end-stage renal disease, is an
autoimmune disease wherein immune complexes consisting of IgA1 with galactose-deficient …

IgA nephropathy, initially described in 1968 as a kidney disease with glomerular
“intercapillary deposits of IgA-IgG”, has no disease-specific treatment and is a common …

A better understanding of the mechanisms underlying the synthesis of galactose-deficient
IgA1, the formation of circulating immune complexes, and interactions with mesangial cells …

The pivotal event in the pathophysiology of IgA nephropathy is the binding of circulating IgA-
containing immune complexes to mesangial cells, with secondary glomerular and …

IgA nephropathy (IgAN) is a complex trait determined by genetic and environmental factors.
Most IgAN patients exhibit a characteristic undergalactosylation of the O-glycans of the IgA1 …