[HTML][HTML] Tumor microenvironment and metabolic remodeling in gemcitabine‐based chemoresistance of pancreatic cancer

Z Gu, Y Du, X Zhao, C Wang - Cancer Letters, 2021 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is a solid malignant tumor with a very low
operative rate and a poor patient prognosis. Therefore, gemcitabine (GEM)-based …

Gemcitabine effects on tumor microenvironment of pancreatic ductal adenocarcinoma: Special focus on resistance mechanisms and metronomic therapies

J Natu, GP Nagaraju - Cancer Letters, 2023 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is considered one of the deadliest malignancies,
with dismal survival rates and extremely prevalent chemoresistance. Gemcitabine is one of …

Complex roles of the stroma in the intrinsic resistance to gemcitabine in pancreatic cancer: where we are and where we are going

C Liang, S Shi, Q Meng, D Liang, S Ji… - … & molecular medicine, 2017 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is among the most devastating human
malignancies. The poor clinical outcome in PDAC is partly attributed to a growth-permissive …

Gemcitabine resistance in pancreatic ductal adenocarcinoma

Y Binenbaum, S Na'ara, Z Gil - Drug resistance updates, 2015 - Elsevier
Pancreatic ductal adenocarcinoma (PDA) ranks fourth among cancer related deaths. The
disappointing 5-year survival rate of below 5% stems from drug resistance to all known …

Molecular and cellular mechanisms of chemoresistance in pancreatic cancer

A Adamska, O Elaskalani, A Emmanouilidi… - Advances in biological …, 2018 - Elsevier
Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most chemoresistant
cancers, and current therapies targeting cancer-associated molecular pathways have not …

Acquired and intrinsic gemcitabine resistance in pancreatic cancer therapy: Environmental factors, molecular profile and drug/nanotherapeutic approaches

M Ashrafizadeh, K Luo, W Zhang, AR Aref… - Environmental …, 2023 - Elsevier
A high number of cancer patients around the world rely on gemcitabine (GEM) for
chemotherapy. During local metastasis of cancers, surgery is beneficial for therapy, but …

Chemoresistance in pancreatic cancer: Emerging concepts

M Gnanamony, CS Gondi - Oncology letters, 2017 - spandidos-publications.com
Pancreatic cancer is one of the most lethal types of cancer in the world. The incidence of
pancreatic cancer increases each year with no significant decrease in mortality. Pancreatic …

Novel discoveries targeting gemcitabine‐based chemoresistance and new therapies in pancreatic cancer: How far are we from the destination?

W Luo, G Yang, J Qiu, J Luan, Y Zhang, L You… - Cancer …, 2019 - Wiley Online Library
Pancreatic cancer (PC) remains one of the deadliest malignancies worldwide.
Chemoresistance is a significant clinical problem in pancreatic ductal adenocarcinoma …

Pancreatic cancer chemoresistance to gemcitabine

M Amrutkar, IP Gladhaug - Cancers, 2017 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC), commonly referred to as pancreatic cancer,
ranks among the leading causes of cancer-related deaths in the Western world due to …

Gemcitabine: a review of chemoresistance in pancreatic cancer

D Sarvepalli, MU Rashid, AU Rahman… - Critical Reviews™ in …, 2019 - dl.begellhouse.com
Pancreatic ductal adenocarcinoma, an exocrine tumor, is the most common type of cancer of
the pancreas and one of the top five most prominent causes of cancer-associated mortality …