Neuroinflammation is a common pathological event observed in many different brain
diseases, frequently associated with blood brain barrier (BBB) dysfunction and followed by …

Aquaporin-4 (AQP4) is a family member of water-channel proteins and is dominantly
expressed in the foot process of glial cells surrounding capillaries. The predominant …

Background Vasogenic edema dynamically accumulates in many brain disorders
associated with brain inflammation, with the critical step of edema exacerbation feared in …

Brain oedema is a major clinical problem produced by CNS diseases (eg stroke, brain
tumour, brain abscess) and systemic diseases that secondarily affect the CNS (eg …

Brain edema is a common feature of brain injuries, which leads to increased intracranial
pressure (ICP) and ischemia that worsen outcome. Current management of edema focuses …

Astrocytes and aquaporin-4 (AQP4) play a significant role in brain ion homeostasis.
Consequently the regulation of AQP4 mRNA in the CNS after different neurological insults …

Summary Aquaporin 4 (AQP 4) is the main water channel in the central nervous system
(CNS) and specifically localized to astrocyte processes. Recent studies indicate that AQP 4 …

Cerebral edema formation stems from disruption of blood brain barrier (BBB) integrity and
occurs after injury to the CNS. Due to the restrictive skull, relatively small increases in brain …

In cerebrovascular disease, edema formation is frequently observed within the first 7 days
and is characterized by molecular and cellular changes in the neurovascular unit. The …

Abstract Aquaporin-4 (AQP4) deficiency in mice reduces neuroinflammation in experimental
autoimmune encephalomyelitis (EAE) produced by active immunization with myelin …