Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic …
Schwann cell transplantation is considered one of the most promising cell-based therapy to
repair injured spinal cord due to its unique growth-promoting and myelin-forming properties …
repair injured spinal cord due to its unique growth-promoting and myelin-forming properties …
Targeting chondroitinase ABC to axons enhances the ability of chondroitinase to promote neurite outgrowth and sprouting
P Day, N Alves, E Daniell, D Dasgupta, R Ogborne… - PloS one, 2020 - journals.plos.org
Background There is currently no effective treatment for promoting regeneration of injured
nerves in patients who have sustained injury to the central nervous system such as spinal …
nerves in patients who have sustained injury to the central nervous system such as spinal …
Chondroitinase ABC plus bone marrow mesenchymal stem cells for repair of spinal cord injury☆
C Zhang, X He, H Li, G Wang - Neural Regeneration Research, 2013 - journals.lww.com
As chondroitinase ABC can improve the hostile microenvironment and cell transplantation is
proven to be effective after spinal cord injury, we hypothesized that their combination would …
proven to be effective after spinal cord injury, we hypothesized that their combination would …
Combining peripheral nerve grafts and chondroitinase promotes functional axonal regeneration in the chronically injured spinal cord
VJ Tom, HR Sandrow-Feinberg, K Miller… - Journal of …, 2009 - Soc Neuroscience
Because there currently is no treatment for spinal cord injury, most patients are living with
long-standing injuries. Therefore, strategies aimed at promoting restoration of function to the …
long-standing injuries. Therefore, strategies aimed at promoting restoration of function to the …
Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances graft cell migration and outgrowth of growth‐associated protein‐43‐positive …
T Ikegami, M Nakamura, J Yamane… - European Journal of …, 2005 - Wiley Online Library
We previously reported that the transplantation of neural stem/progenitor cells (NSPCs) can
contribute to the repair of injured spinal cord in adult rats and monkeys. In some cases …
contribute to the repair of injured spinal cord in adult rats and monkeys. In some cases …
Chondroitinase ABC promotes axonal re-growth and behavior recovery in spinal cord injury
WC Huang, WC Kuo, JH Cherng, SH Hsu… - Biochemical and …, 2006 - Elsevier
In spinal cord injury, the injury could trigger some inhibitory signal cascades to promote
chondroitin sulfate proteoglycans (CSPGs), the structures of scar tissues, formation. CSPGs …
chondroitin sulfate proteoglycans (CSPGs), the structures of scar tissues, formation. CSPGs …
Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome …
JM Massey, J Amps, MS Viapiano, RT Matthews… - Experimental …, 2008 - Elsevier
Increased chondroitin sulfate proteoglycan (CSPG) expression in the vicinity of a spinal cord
injury (SCI) is a primary participant in axonal regeneration failure. However, the presence of …
injury (SCI) is a primary participant in axonal regeneration failure. However, the presence of …
Combination treatment with chondroitinase ABC in spinal cord injury—breaking the barrier
RR Zhao, JW Fawcett - Neuroscience bulletin, 2013 - Springer
After spinal cord injury (SCI), re-establishing functional circuitry in the damaged central
nervous system (CNS) faces multiple challenges including lost tissue volume, insufficient …
nervous system (CNS) faces multiple challenges including lost tissue volume, insufficient …
The yellow fluorescent protein (YFP-H) mouse reveals neuroprotection as a novel mechanism underlying chondroitinase ABC-mediated repair after spinal cord injury
LM Carter, ML Starkey, SF Akrimi, M Davies… - Journal of …, 2008 - Soc Neuroscience
Chondroitinase ABC (ChABC) represents a promising therapeutic strategy for the treatment
of spinal cord injury due to its potent effects on restoring function to spinal-injured adult …
of spinal cord injury due to its potent effects on restoring function to spinal-injured adult …
Chondroitinase ABC enhances axonal regrowth through Schwann cell‐seeded guidance channels after spinal cord injury
CH Chau, DKY Shum, H Li, J Pei, YY Lui… - The FASEB …, 2004 - Wiley Online Library
Grafting of Schwann cell‐seeded channels into hemisected adult rat thoracic spinal cords
has been tested as a strategy to bridge the injured cord. Despite success in guiding axonal …
has been tested as a strategy to bridge the injured cord. Despite success in guiding axonal …
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