Schwann cell transplantation is considered one of the most promising cell-based therapy to
repair injured spinal cord due to its unique growth-promoting and myelin-forming properties …

Background There is currently no effective treatment for promoting regeneration of injured
nerves in patients who have sustained injury to the central nervous system such as spinal …

As chondroitinase ABC can improve the hostile microenvironment and cell transplantation is
proven to be effective after spinal cord injury, we hypothesized that their combination would …

Because there currently is no treatment for spinal cord injury, most patients are living with
long-standing injuries. Therefore, strategies aimed at promoting restoration of function to the …

We previously reported that the transplantation of neural stem/progenitor cells (NSPCs) can
contribute to the repair of injured spinal cord in adult rats and monkeys. In some cases …

In spinal cord injury, the injury could trigger some inhibitory signal cascades to promote
chondroitin sulfate proteoglycans (CSPGs), the structures of scar tissues, formation. CSPGs …

Increased chondroitin sulfate proteoglycan (CSPG) expression in the vicinity of a spinal cord
injury (SCI) is a primary participant in axonal regeneration failure. However, the presence of …

After spinal cord injury (SCI), re-establishing functional circuitry in the damaged central
nervous system (CNS) faces multiple challenges including lost tissue volume, insufficient …

Chondroitinase ABC (ChABC) represents a promising therapeutic strategy for the treatment
of spinal cord injury due to its potent effects on restoring function to spinal-injured adult …

Grafting of Schwann cell‐seeded channels into hemisected adult rat thoracic spinal cords
has been tested as a strategy to bridge the injured cord. Despite success in guiding axonal …