We performed genome-wide sequencing and analyzed mRNA and miRNA expression, DNA
copy number, and DNA methylation in 117 Wilms tumors, followed by targeted sequencing …

Background Wilms tumour is the most common childhood renal cancer and is genetically
heterogeneous. While several Wilms tumour predisposition genes have been identified …

The evolution of pediatric solid tumors is poorly understood. There is conflicting evidence of
intra-tumor genetic homogeneity vs. heterogeneity (ITGH) in a small number of studies in …

Wilms tumour is the most common renal malignancy of childhood. The disease is curable in
the majority of cases, albeit at considerable cost in terms of late treatment-related effects in …

The past decade has witnessed substantial growth in our knowledge of the genes and loci
that are altered in Wilms tumor. Although Wilms tumor was one of the original paradigms of …

Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups.
Here, to identify mutations that drive medulloblastoma, we sequenced the entire genomes of …

Background Wilms tumor (WT) has a not completely elucidated pathogenesis. DNA copy
number alterations (CNAs) are common in cancer, and often define key pathogenic events …

Wilms tumors (WT) have provided broad insights into the interface between development
and tumorigenesis. Further understanding is confounded by their genetic, histologic, and …

Somatic defects at five loci, WT1, CTNNB1, WTX, TP53 and the imprinted 11p15 region, are
implicated in Wilms tumor, the commonest childhood kidney cancer. In this study we …

Studies of paediatric cancers have shown a high frequency of mutation across epigenetic
regulators. Here we sequence 633 genes, encoding the majority of known epigenetic …