Cystic fibrosis is a genetic disease that results in progressive multi-organ manifestations with
predominance in the respiratory and gastrointestinal systems. The significant morbidity and …

Introduction: Cystic fibrosis (CF) is an autosomal dominant chloride channelopathy caused
by mutations in the CF transmembrane conductance regulator (CFTR) gene that results …

Cystic fibrosis (CF) is an autosomal recessive disorder characterized by chronic lung and
sinus disease, impaired mucociliary clearance (leading to recurrent pulmonary infection) …

Introduction Cystic fibrosis (CF) is a genetic disease affecting multiple organ systems.
Research and innovations in novel therapeutic agents and health care delivery have …

Introduction: Cystic fibrosis is an autosomal recessive disease, which is the result of a
genetic defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene …

Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis
transmembrane conductance regulator (CFTR), an anion channel expressed in epithelial …

Introduction: Cystic fibrosis (CF) is a multisystem illness caused by abnormalities in the CF
transmembrane conductance regulator (CFTR) gene and protein. CFTR is an ion channel …

Objectives Study of currently approved drugs and exploration of future clinical development
pipeline therapeutics for cystic fibrosis, and possible limitations in their use. Methods …

With the 2019 breakthrough in the development of highly effective modulator therapy
providing unprecedented clinical benefits for over 90% of patients with cystic fibrosis who …

The advent of Cystic fibrosis transmembrane receptor (CFTR) modulators in 2012 was a
critical event in the history of cystic fibrosis (CF) treatment. Unlike traditional therapies that …