In this paper a series of new 1, 3, 4-thiadiazole derivatives has been designed, synthesized
and evaluated as the acetyl-and butyrylcholinesterase inhibitors. Some analogues showed …

Nineteen new thiazole-based derivatives were synthesized and their structures
characterized with analytical and spectral data. The in vitro assessment of their …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder worldwide.
Currently, the only strategy for palliative treatment of AD is to inhibit acetylcholinesterase …

In the present study, new (1, 3, 4-thiadiazol-2-yl) benzene-1, 3-diol based compounds have
been synthesized and their potential anticholinesterases properties have been investigated …

A series of 20 novel benzimidazole and benzothiazole derivatives linked to a 1, 2, 3-triazole
ring system was synthesised, characterised and evaluated for in vitro acetylcholinesterase …

In this work, a series of derivatives containing 1, 2, 3-triazole and isoxazole were
synthesized. All of them were evaluated as novel dual AChE inhibitors. Most of synthesized …

Two series of novel pyrazolobenzothiazine-based hybrid compounds were efficiently
synthesized starting from saccharin sodium salt. Pyrazolo [4, 3-c][1, 2] benzothiazine …

In the current study, 14 new benzothiazole–piperazine compounds were designed to meet
the structural requirements of acetylcholine esterase (AChE) inhibitors. The target …

In this work, a novel series of arylisoxazole‐phenylpiperazines were designed, synthesized,
and evaluated toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Our …

A series of iV-benzylpiperidine benzisoxazoles has been developed as potent and selective
inhibitors of the enzyme acetylcholinesterase (AChE). The benzisoxazole heterocycle was …