Transcriptional control is crucial for normal cellular development and is regulated through a
host of mechanisms. Among other methods, cells control transcription across the genome …

Lipids are present within the cell nucleus where they engage with factors involved in gene
regulation. Cholesterol associates with chromatin in vivo and stimulates nucleosome …

Lipids are present within the cell nucleus, where they engage with factors involved in gene
regulation. Cholesterol associates with chromatin in vivo and stimulates nucleosome …

The transcriptional corepressor BASP1 requires N-terminal myristoylation for its activity and
functions through interactions with nuclear lipids. Here we determine the role of BASP1 …

Multiple mechanisms influence transcriptional control, with mounting evidence proving that
gene expression is directly correlated to the accessibility of the DNA sequence to RNA …

We have evaluated the mechanism for sterol-regulated gene expression by the sterol
regulatory element binding proteins (SREBPs) in intact cells. We show that activation of …

The Wilms' tumour suppressor protein WT1 plays a central role in the development of the
kidney and also other organs. WT1 can act as a transcription factor with highly context …

Although best known as a risk factor for cardiovascular disease, cholesterol is a vital
component of all mammalian cells. In addition to key structural roles, cholesterol is a vital …

Sterol regulation of gene expression in mammalian cells is mediated by an interaction
between the cholesterol-sensitive sterol regulatory element-binding proteins (SREBPs) and …

Background Eukaryotic gene expression is a complex process involving multiple cis and
trans activating molecules to either facilitate or inhibit transcription. In recent years, many …