Chrysophanol alleviates acute lung injury caused by Klebsiella pneumoniae infection by inhibiting pro‐inflammatory cytokine production

F Jiang, J Jiang, W He, G Dong, N Xu… - Phytotherapy …, 2023 - Wiley Online Library
Acute lung injury (ALI) caused by acute bacterial infection remains a common life‐
threatening lung disease. An increased inflammatory response is the basis for the …

Chrysophanol exerts anti-inflammatory activity by targeting histone deacetylase 3 through the high mobility group protein 1-nuclear transcription factor-kappa B …

Q Wen, N Lau, H Weng, P Ye, S Du, C Li… - … in bioengineering and …, 2021 - frontiersin.org
Chrysophanol (Chr) is the main monomer isolated from Rheum rhabarbarum. This study
aimed to identify the potential in vitro and in vivo cytoprotective effects of Chr on …

Hydnocarpin D attenuates lipopolysaccharide-induced acute lung injury via MAPK/NF-κB and Keap1/Nrf2/HO-1 pathway

H Hong, S Lou, F Zheng, H Gao, N Wang, S Tian… - Phytomedicine, 2022 - Elsevier
Background Acute lung injury (ALI) is a complex pulmonary destructive disease with limited
therapeutic approaches. Hydnocarpin D (HD) is a flavonolignan isolated from Hydnocarpus …

Chrysin prevents lipopolysaccharide-induced acute lung injury in mice by suppressing the IRE1α/TXNIP/NLRP3 pathway

M Chen, J Li, X Liu, Z Song, S Han, R Shi… - Pulmonary Pharmacology …, 2021 - Elsevier
Acute lung injury (ALI) remains a serious challenge in the intensive care unit. Inflammation
plays a key role in the progression of ALI. Chrysin (CHR) is a natural flavonoid with anti …

Chelerythrine attenuates the inflammation of lipopolysaccharide-induced acute lung inflammation through NF-κB signaling pathway mediated by Nrf2

L Fan, Y Fan, L Liu, W Tao, X Shan, Y Dong… - Frontiers in …, 2018 - frontiersin.org
Chelerythrine (CH), is a kind of benzo [c] phenanthridine alkaloid isolated from plants such
as Chelidonium, with pharmacological activities as antitumor, antibiosis and anti …

Acacetin Attenuates Sepsis-induced Acute Lung Injury via NLRC3-NF-κB Pathway

Y Xiao, B Zhang, S Hou, X Shen, X Wu, R Liu, Y Luo - Inflammation, 2024 - Springer
Acacetin, a flavonoid derived compound has been recognized for its diverse biological
activities, such as anti-oxidative and anti-inflammatory effects. Acute lung injury (ALI) is a …

The Therapeutic Potential of (+)-Afzelechin for Alleviating Sepsis-Associated Pulmonary Injury

S Cho, YJ Park, E Kim, JS Bae - Journal of Medicinal Food, 2024 - liebertpub.com
Sepsis-induced acute lung injury (ALI) poses a common and formidable challenge in clinical
practice, currently lacking efficacious therapeutic approaches. This study delves into the …

Acacetin protects against acute lung injury by upregulating SIRT1/NF-κB pathway

L Gu, Y Yin, M Liu, Y Lu - Heliyon, 2024 - cell.com
Acacetin is one of the natural flavone components found in many plants and possesses
diverse pharmacological activities. The anti-inflammatory properties and definite mechanism …

Exocarpium Citri Grandis ameliorates LPS-induced acute lung injury by suppressing inflammation, NLRP3 inflammasome, and ferroptosis

Z Xu, J Li, K Zhou, K Wang, H Hu, Y Hu, Y Gao… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Exocarpium Citri Grandis (ECG), the epicarp of C.
grandis 'Tomentosa'which is also known as Hua-Ju-Hong in China, has been widely used …

Chrysophanol attenuates airway inflammation and remodeling through nuclear factor‐kappa B signaling pathway in asthma

G Song, Y Zhang, S Yu, W Lv, Z Guan… - Phytotherapy …, 2019 - Wiley Online Library
Chrysophanol (CHR), a purified active constituent extracted from Rheum palmatum L.,
possesses anti‐inflammatory activity. This study aimed to evaluate its effects on asthma …