Nowadays, searching for new anti-infective agents with diverse mechanisms of action has
become necessary. In this study, 16 pyrazole and pyrazolo [1, 5-a] pyrimidine derivatives …

Carbonic anhydrases (CAs, EC 4.2. 1.1) catalyze the essential reaction of CO2 hydration in
all living organisms, being actively involved in the regulation of a plethora of patho …

A series of novel 1 H-1, 2, 3-triazole analogs (9a–j) were synthesized via “Click” chemistry
and Suzuki–Miyaura cross-coupling reaction in aqueous medium. The compounds were …

Abstract Carbonic anhydrases (CA, EC 4.2. 1.1) are Zinc metalloenzymes and are present
throughout most living organisms. Among the catalytically active isoforms are the cytosolic …

A series of 24 novel heterocyclic compounds—functionalized at position 4 with aldehyde (5a–
5f), carboxylic acid (6a–6f), nitrile (7a–7f) and oxime (8a–8f) functional groups—bearing 6 …

This study aimed to design potent carbonic anhydrase inhibitors (CAIs) based on pyrazole
benzenesulfonamide core. Nine series of substituted pyrazole benzenesulfonamide …

Herein, we report the design and synthesis of two series of pyrazole‐tethered sulfamoyl
phenyl acetamides and pyrazole‐tethered sulfamoyl phenyl benzamides. The synthesized …

Sulfonamides are among the most promising potential inhibitors for carbonic anhydrases
(CAs), which are pharmaceutically relevant targets for treating several disease conditions …

Changes in gene expression cause uncontrolled cell proliferation and consequently tumor
hypoxia. The tumor cells shift their metabolism to anaerobic glycolysis with a significant …

A library of twenty-two arylthiazolylhydrazono-1, 2, 3-triazoles incorporating sulfanilamide
and metanilamide moieties have been synthesized by utilizing tail-approach and …