Microglia have emerged as a critical component of neurodegenerative diseases. Genetic
manipulation of microglia can elucidate their functional impact in disease. In neuroscience …

As the resident immune cells in the central nervous system (CNS), microglia orchestrate
immune responses and dynamically sculpt neural circuits in the CNS. Microglial dysfunction …

Microglia represent a crucial cell population in the central nervous system, participating in
the regulation and surveillance of physiological processes as well as playing key roles in the …

Recombinant adeno-associated viruses (rAAV) have been widely used in gene therapy
applications for central nervous system diseases. Though rAAV can efficiently target …

Astrocytes are involved in key physiological brain processes, such as glutamatergic
transmission and energy metabolism, often altered in neurodegenerative diseases …

Adeno-associated viral (AAV) vectors are a rapidly emerging gene therapy platform for the
treatment of neurological diseases. In preclinical studies, transgenes encoding therapeutic …

Functional studies of resident microglia require molecular tools for their genetic
manipulation. Here we show that microRNA-9-regulated lentiviral vectors can be used for …

The natural tropism of most viral vectors, including adeno-associated viral (AAV) vectors,
leads to predominant transduction of neurons and epithelia within the central nervous …

Gene therapy for neurological disorders has attracted significant interest as a way to reverse
or stop various disease pathologies. Typical gene therapies involving the central and …

Gliomas are primary, diffusely infiltrating brain tumors. Microglia are innate immune cells in
the CNS and make up a substantial portion of the tumor mass. Glioma cells shape their …