Strategies and challenges in method development and validation for the absolute quantification of endogenous biomarker metabolites using liquid chromatography …

MM Khamis, DJ Adamko… - Mass spectrometry …, 2021 - Wiley Online Library
Metabolomics is a dynamically evolving field, with a major application in identifying
biomarkers for drug development and personalized medicine. Numerous metabolomic …

Metabolomics in the clinic: A review of the shared and unique features of untargeted metabolomics for clinical research and clinical testing

AD Kennedy, BM Wittmann, AM Evans… - Journal of Mass …, 2018 - Wiley Online Library
Metabolomics is the untargeted measurement of the metabolome, which is composed of the
complement of small molecules detected in a biological sample. As such, metabolomic …

Challenges in mass spectrometry based targeted metabolomics

T Koal, HP Deigner - Current molecular medicine, 2010 - ingentaconnect.com
The gap of the post-genomic era is increasingly being filled by the metabolomics approach,
comprising a technology for analyzing small molecule endogenous metabolites (≤ 1500 …

Metabolomics analysis for biomarker discovery: advances and challenges

MS Monteiro, M Carvalho, ML Bastos… - Current medicinal …, 2013 - ingentaconnect.com
Over the last decades there has been a change in biomedical research with the search for
single genes, transcripts, proteins, or metabolites being substituted by the coverage of the …

[HTML][HTML] A framework for development of useful metabolomic biomarkers and their effective knowledge translation

CR Marchand, F Farshidfar, J Rattner, OF Bathe - Metabolites, 2018 - mdpi.com
Despite the significant advantages of metabolomic biomarkers, no diagnostic tests based on
metabolomics have been introduced to clinical use. There are many reasons for this …

[HTML][HTML] From differentiating metabolites to biomarkers

A Koulman, GA Lane, SJ Harrison… - Analytical and bioanalytical …, 2009 - Springer
The current developments in metabolomics and metabolic profiling technologies have led to
the discovery of several new metabolic biomarkers. Finding metabolites present in …

How unbiased is non-targeted metabolomics and is targeted pathway screening the solution?

U Christians, J Klawitter, A Hornberger… - Current …, 2011 - ingentaconnect.com
Metabolomics is only truly unbiased if the whole metabolome is captured. Current
metabolomics technologies capture only a part of the metabolome and therefore produce …

[HTML][HTML] Translational biomarker discovery in clinical metabolomics: an introductory tutorial

J Xia, DI Broadhurst, M Wilson, DS Wishart - Metabolomics, 2013 - Springer
Metabolomics is increasingly being applied towards the identification of biomarkers for
disease diagnosis, prognosis and risk prediction. Unfortunately among the many published …

[HTML][HTML] Progress in metabolomics standardisation and its significance in future clinical laboratory medicine

DA Dias, T Koal - Ejifcc, 2016 - ncbi.nlm.nih.gov
Today, the technology of 'targeted'based metabolomics is pivotal in the clinical analysis
workflow as it provides information of metabolic phenotyping (metabotypes) by enhancing …

[HTML][HTML] The search for clinically useful biomarkers of complex disease: a data analysis perspective

EC Considine - Metabolites, 2019 - mdpi.com
Unmet clinical diagnostic needs exist for many complex diseases, which it is hoped will be
solved by the discovery of metabolomics biomarkers. However, as yet, no diagnostic tests …