Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …

Parkinson's disease (PD) is characterized by the accumulation of misfolded and aggregated
α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is …

Cytoplasmic inclusions containing α-synuclein (α-Syn) fibrils, referred to as Lewy bodies
(LBs), are the signature neuropathological hallmarks of Parkinson's disease (PD). Although …

Summary Lewy bodies (LBs) and Lewy neurites (LNs), comprised of alpha-synuclein (aSyn),
are intraneuronal inclusions that characterize Parkinson's disease. Although the association …

Inclusions composed of α-synuclein (α-syn), ie, Lewy bodies (LBs) and Lewy neurites (LNs),
define synucleinopathies including Parkinson's disease (PD) and dementia with Lewy …

Formation and accumulation of misfolded protein aggregates are a central hallmark of
several neurodegenerative diseases. In Parkinson's disease (PD), the aggregation-prone …

Several lines of evidence from neuropathological studies, human genetics, in vitro
aggregation studies and cellular and animal models support the hypothesis that aSyn plays …

Extraction of α-Synuclein (αSyn) aggregates from Lewy body disease (LBD) brains has been
widely described yet templated fibrillization of LB-αSyn often fails to propagate its structural …

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are both characterized
pathologically by the presence of neuronal inclusions termed Lewy bodies (LBs). A common …

Synucleinopathies are a group of neurodegenerative disorders associated with the
formation of aberrant amyloid inclusions composed of the normally soluble presynaptic …