This chapter reviews the cell transplantation strategies that have been explored as potential
options in the treatment of pain and traumatic brain injury (TBI). As the goals of these two …

Cell therapy to treat neuropathic pain after spinal cord injury (SCI) is in its infancy. However,
the development of cellular strategies that would replace or be used as an adjunct to …

Traumatic brain injury (TBI) is one of the leading causes of death and disabilities worldwide.
It affects approximately 1.5 million people each year and is associated with severe post-TBI …

The transplantation of cells into the CNS has been considered a promising long-term
therapeutic approach in the management of neurological disorders. Cell transplantation can …

Cell transplantation is a potentially powerful approach for the alleviation of chronic pain. The
strategy of cell transplantation for the treatment of pain is focused on cell-based analgesia …

Among many mechanisms implicated in the development of neuropathic pain after nerve
damage is a profound dysfunction of GABAergic inhibitory controls, manifested by ongoing …

Neural stem/progenitor cells capable of generating new neurons and glia, reside in specific
areas of the adult mammalian central nervous system (CNS), including the ependymal …

Despite recent advances in the understanding of mechanisms underlying persistent pain
development and maintenance, the therapeutic management of chronic pain remains a …

Experimental research during the past decade has greatly increased our understanding of
the pathophysiology of traumatic brain injury (TBI) and allowed us to develop …

Effective treatment of sensory neuropathies in peripheral neuropathies and spinal cord
injury (SCI) is one of the most difficult problems in modern clinical practice. Cell therapy to …