Lysosomes serve as degradation hubs for the turnover of endocytic and autophagic cargos,
which is essential for neuron function and survival. Deficits in lysosome function result in …

Highlights•Lysosomes degrade diverse cargos that are captured within endosomes and
autophagosomes.•Lysosome abundance in axons is limited by efficient retrograde transport …

Neurons face the challenge of maintaining cellular homeostasis through lysosomal
degradation. While enzymatically active degradative lysosomes are enriched in the soma …

Lysosomes, single-membrane organelles defined by a uniquely strong acidic lumenal pH
and high content of acid hydrolases, are the shared degradative compartments of the …

Lysosomal trafficking and maturation in neurons remain poorly understood and are
unstudied in vivo despite high disease relevance. We generated neuron-specific transgenic …

Neurons, because of their elaborate morphology and the long distances between distal
axons and the soma as well as their longevity, pose special challenges to autophagy and to …

How do neurons adapt their endolysosomal system to address the particular challenge of
membrane transport across their elaborate cellular landscape and to maintain proteostasis …

Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …

Autophagy and endocytic trafficking are two key pathways that regulate the composition and
integrity of the neuronal proteome. Alterations in these pathways are sufficient to cause …

Neurons extend long axons that require maintenance and are susceptible to degeneration.
Long-term integrity of axons depends on intrinsic mechanisms including axonal transport …