Pancreatic islets are highly interconnected structures that produce pulses of insulin and
other hormones, maintaining normal homeostasis of glucose and other nutrients. Normal …

Beta cells within the pancreatic islets of Langerhans respond to stimulation with coherent
oscillations of membrane potential and intracellular calcium concentration that presumably …

Pancreatic islets produce pulses of insulin and other hormones that maintain normal
glucose homeostasis. These micro-organs possess exquisite glucose-sensing capabilities …

Insulin is released from the islets of Langerhans in discrete pulses that are linked to
synchronized oscillations of intracellular free calcium ([Ca 2+] i). Associated with each …

Major part of a pancreatic islet is composed of β-cells that secrete insulin, a key hormone
regulating influx of nutrients into all cells in a vertebrate organism to support nutrition …

Pancreatic islet hormones regulate blood glucose homeostasis. Changes in blood glucose
induce oscillations of cytosolic calcium in pancreatic islet cells that trigger secretion of three …

Homeostasis of blood glucose is mainly regulated by the coordinated secretion of glucagon
and insulin from α-and β-cells within the islets of Langerhans. The release of both hormones …

In endocrine cells within islets of Langerhans calcium ions couple cell stimulation to
hormone secretion. Since the advent of modern fluorimetry, numerous in vitro studies …

Oscillatory electrical activity is regarded as a hallmark of the pancreatic beta cell glucose-
dependent excitability pattern. Electrophysiologically recorded membrane potential …

At intermediate glucose concentrations,[Ca2+] i (intracellular calcium) measured in single
islets of Langerhans undergo oscillations that are caused by glucose-induced bursting of …