Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex
M Bharadwaj, P Illing, A Theodossis… - Annual review of …, 2012 - annualreviews.org
The human leukocyte antigen (HLA) genes are the most polymorphic in the human genome
and are critical in regulating specific immunity, hence their historical discovery as “immune …
and are critical in regulating specific immunity, hence their historical discovery as “immune …
Human leukocyte antigen-associated drug hypersensitivity
A growing number of associations between adverse drug reactions and alleles of the human
leukocyte antigen (HLA) genes are now known. Although several models have been …
leukocyte antigen (HLA) genes are now known. Although several models have been …
Human leukocyte antigens (HLA) associated drug hypersensitivity: consequences of drug binding to HLA
J Yun, J Adam, D Yerly, WJ Pichler - Allergy, 2012 - Wiley Online Library
Recent publications have shown that certain human leukocyte antigen (HLA) alleles are
strongly associated with hypersensitivity to particular drugs. As HLA molecules are a critical …
strongly associated with hypersensitivity to particular drugs. As HLA molecules are a critical …
Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions
Highlights•Studies of HLA/ADR associations suggest diverse modes of HLA–drug
interaction.•Non-covalent interactions with HLA-peptide appear highly allotype …
interaction.•Non-covalent interactions with HLA-peptide appear highly allotype …
Immunopharmacogenomics: mechanisms of HLA‐associated drug reactions
P Deshpande, RJ Hertzman… - Clinical …, 2021 - Wiley Online Library
The human leukocyte antigen (HLA) system is the most polymorphic in the human genome
that has been associated with protection and predisposition to a broad array of infectious …
that has been associated with protection and predisposition to a broad array of infectious …
HLA and pharmacogenetics of drug hypersensitivity
Immunologically mediated drug reactions have been traditionally classified as unpredictable
based on the fact that they cannot be predicted strictly on the pharmacological action of the …
based on the fact that they cannot be predicted strictly on the pharmacological action of the …
T cell–mediated hypersensitivity reactions to drugs
The immunological mechanisms driving delayed hypersensitivity reactions (HSRs) to drugs
mediated by drug-reactive T lymphocytes are exemplified by several key examples and their …
mediated by drug-reactive T lymphocytes are exemplified by several key examples and their …
The role of HLA genes in pharmacogenomics: unravelling HLA associated adverse drug reactions
Genetic polymorphism in the genes encoding the human leukocyte antigen (HLA) molecules
enables presentation of a wide range peptide ligands thus maximising immune surveillance …
enables presentation of a wide range peptide ligands thus maximising immune surveillance …
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire
Idiosyncratic adverse drug reactions are unpredictable, dose-independent and potentially
life threatening; this makes them a major factor contributing to the cost and uncertainty of …
life threatening; this makes them a major factor contributing to the cost and uncertainty of …
Genetic factors in the predisposition to drug-induced hypersensitivity reactions
M Pirmohamed - The AAPS journal, 2006 - Springer
Drug hypersensitivity reactions can occur with most drugs, although the frequency, severity,
and clinical manifestations vary. Case reports have suggested that there may be familial …
and clinical manifestations vary. Case reports have suggested that there may be familial …