TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology

M Morikawa, R Derynck… - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
The transforming growth factor-β (TGF-β) is the prototype of the TGF-β family of growth and
differentiation factors, which is encoded by 33 genes in mammals and comprises homo-and …

Transforming growth factor‐β: The breaking open of a black box

A Alevizopoulos, N Mermod - Bioessays, 1997 - Wiley Online Library
Transforming growth factor‐β (TGF‐β) and its related proteins regulate broad aspects of
body development, including cell proliferation, differentiation, apoptosis and gene …

The discovery and early days of TGF-β: a historical perspective

HL Moses, AB Roberts… - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Transforming growth factors (TGFs) were discovered as activities that were secreted by
cancer cells, and later by normal cells, and had the ability to phenotypically and reversibly …

Transforming growth factor-beta 3.

DA Cox - Cell biology international, 1995 - Elsevier
Transforming Growth Factor-Beta (TGF-β) is the general name for a family of naturally-
occurring polypeptides which have multiple regulatory effects on cell proliferation and …

Function of cytokines within the TGF-β superfamily as determined from transgenic and gene knockout studies in mice

AB Kulkarni, T Thyagarajan… - Current molecular …, 2002 - ingentaconnect.com
Several major conceptual problems regarding specific in vivo functions of the TGF-β family
members remain the key focus of many researchers studying the biology of these secreted …

The cell biology of transforming growth factor β

JA Barnard, RM Lyons, HL Moses - … et Biophysica Acta (BBA)-Reviews on …, 1990 - Elsevier
The TGFβ family of polypeptide growth factors regulates a remarkable diversity of cellular
functions, many of which are not directly associated with cell growth. The present review has …

TGF-b signaling in development and disease

J Massagué - Febs Lett, 2012 - core.ac.uk
The articles assembled in this especial issue of FEBS Letters review current progress and
perspectives on various aspects of transforming growth factor b (TGF-b) signaling in …

Genealogy, expression, and cellular function of transforming growth factor-β

R Govinden, KD Bhoola - Pharmacology & therapeutics, 2003 - Elsevier
The transforming growth factor-β (TGF-β) gene superfamily expresses a large set of
structurally and functionally related polypeptides. Three TGF-β isoforms are regulated by …

TGF-β/TGF-β receptor system and its role in physiological and pathological conditions

JF Santibañez, M Quintanilla, C Bernabeu - Clinical science, 2011 - portlandpress.com
The TGF-β (transforming growth factor-β) system signals via protein kinase receptors and
Smad mediators to regulate a plethora of biological processes, including morphogenesis …

The dual role of TGFβ in human cancer: from tumor suppression to cancer metastasis

JJ Lebrun - International Scholarly Research Notices, 2012 - Wiley Online Library
The transforming growth factor‐beta (TGFβ) superfamily encompasses widespread and
evolutionarily conserved polypeptide growth factors that regulate and orchestrate growth …