Ion channels as molecular targets of glioblastoma electrotherapy

T Abed, K Ganser, F Eckert, N Stransky… - Frontiers in Cellular …, 2023 - frontiersin.org
Therapies with weak, non-ionizing electromagnetic fields comprise FDA-approved
treatments such as Tumor Treating Fields (TTFields) that are used for adjuvant therapy of …

Permeabilizing cell membranes with electric fields

AA Aguilar, MC Ho, E Chang, KW Carlson, A Natarajan… - Cancers, 2021 - mdpi.com
Simple Summary The FDA recently approved a fourth approach (in addition to surgery,
radiation therapy, and chemotherapy) for treating glioblastoma; namely, tumor treating fields …

Electrotherapies for glioblastoma

EPW Jenkins, A Finch, M Gerigk, IF Triantis… - Advanced …, 2021 - Wiley Online Library
Abstract Non‐thermal, intermediate frequency (100–500 kHz) electrotherapies present a
unique therapeutic strategy to treat malignant neoplasms. Here, pulsed electric fields (PEFs) …

Tumor treating fields increases membrane permeability in glioblastoma cells

E Chang, CB Patel, C Pohling, C Young, J Song… - Cell death …, 2018 - nature.com
Glioblastoma is the most common yet most lethal of primary brain cancers with a one-year
post-diagnosis survival rate of 65% and a five-year survival rate of barely 5%. Recently the …

Alternating Electric Fields (TTFields) Activate Cav1.2 Channels in Human Glioblastoma Cells

E Neuhaus, L Zirjacks, K Ganser, L Klumpp, U Schüler… - Cancers, 2019 - mdpi.com
Tumor treating fields (TTFields) represent a novel FDA-approved treatment modality for
patients with newly diagnosed or recurrent glioblastoma multiforme. This therapy applies …

Ion channels as therapeutic targets in high grade gliomas

M Griffin, R Khan, S Basu, S Smith - Cancers, 2020 - mdpi.com
Simple Summary Glioblastoma multiforme is an aggressive grade IV lethal brain tumour with
a median survival of 14 months. Despite surgery to remove the tumour, and subsequent …

[HTML][HTML] Current status of the preclinical evaluation of alternating electric fields as a form of cancer therapy

C Pohling, H Nguyen, E Chang, KE Schubert, Y Nie… - …, 2023 - Elsevier
Exposing cancer cells to alternating electric fields of 100-300 kHz frequency and 1-4 V/cm
strength has been shown to significantly reduce cancer growth in cell culture and in human …

Integrating flexible electronics for pulsed electric field delivery in a vascularized 3D glioblastoma model

MC Lefevre, G Dijk, A Kaszas, M Baca… - Npj Flexible …, 2021 - nature.com
Glioblastoma is a highly aggressive brain tumor, very invasive and thus difficult to eradicate
with standard oncology therapies. Bioelectric treatments based on pulsed electric fields …

Tumor treating fields exert cellular and immunologic effects

ET Wong, J Timmons, KD Swanson - Cancer Research, 2018 - AACR
While there is clear clinical evidence to support the therapeutic efficacy of low dose
alternating electric fields (TTFields) in treating glioblastoma, their intracellular targets and …

Ion channel drugs suppress cancer phenotype in NG108-15 and U87 cells: toward novel electroceuticals for glioblastoma

J Mathews, F Kuchling, D Baez-Nieto, M Diberardinis… - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma is a rapidly progressing brain cancer that is very difficult to
treat. Given that many aspects of cell and tissue behavior are controlled by electric signaling …