Dietary phytochemicals as modulators of human pregnane X receptor
As a promiscuous xenobiotic sensor, pregnane X receptor (PXR) plays a crucial role in drug
metabolism. Since dietary phytochemicals exhibit the potential to modulate human PXR, this …
metabolism. Since dietary phytochemicals exhibit the potential to modulate human PXR, this …
[HTML][HTML] PXR as a mediator of herb–drug interaction
BC Hogle, X Guan, MM Folan, W Xie - journal of food and drug analysis, 2018 - Elsevier
Medicinal herbs have been a part of human medicine for thousands of years. The herb–drug
interaction is an extension of drug–drug interaction, in which the consumptions of herbs …
interaction is an extension of drug–drug interaction, in which the consumptions of herbs …
Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer
Pregnane X receptor (PXR) is a ligand‐activated nuclear receptor (NR) that was originally
identified as a master regulator of xenobiotic detoxification. It regulates the expression of …
identified as a master regulator of xenobiotic detoxification. It regulates the expression of …
Garcinoic acid is a natural and selective agonist of pregnane X receptor
Pregnane X receptor (PXR) is a master xenobiotic-sensing transcription factor and a
validated target for immune and inflammatory diseases. The identification of chemical …
validated target for immune and inflammatory diseases. The identification of chemical …
Identification of novel pregnane X receptor activators from traditional Chinese medicines
C Yu, X Chai, L Yu, S Chen, S Zeng - Journal of ethnopharmacology, 2011 - Elsevier
Aim of the study To investigate the ability of traditional Chinese medicines (TCMs) and their
bioactive compounds to activate pregnane X receptor (PXR) signalling pathway. Materials …
bioactive compounds to activate pregnane X receptor (PXR) signalling pathway. Materials …
Identification of clinically used drugs that activate pregnane X receptors
SJ Shukla, S Sakamuru, R Huang, TA Moeller… - Drug Metabolism and …, 2011 - ASPET
The pregnane X receptor (PXR) binds xenobiotics and regulates the expression of several
drug-metabolizing enzymes and transporters. Human PXR (hPXR) activation and CYP3A4 …
drug-metabolizing enzymes and transporters. Human PXR (hPXR) activation and CYP3A4 …
[HTML][HTML] The role of pregnane X receptor (PXR) in substance metabolism
Y Lv, YY Luo, HW Ren, CJ Li, ZX Xiang… - Frontiers in …, 2022 - frontiersin.org
As a member of the nuclear receptor (NR) superfamily, pregnane X receptor (PXR; NR1I2) is
a ligand-activated transcription factor that plays a crucial role in the metabolism of …
a ligand-activated transcription factor that plays a crucial role in the metabolism of …
PXR: more than just a master xenobiotic receptor
PO Oladimeji, T Chen - Molecular pharmacology, 2018 - ASPET
Pregnane X receptor (PXR) is a nuclear receptor considered to be a master xenobiotic
receptor that coordinately regulates the expression of genes encoding drug-metabolizing …
receptor that coordinately regulates the expression of genes encoding drug-metabolizing …
Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study
The pregnane X receptor (PXR) plays a critical role in the regulation of human cytochrome
P450 3A4 (CYP3A4) gene. In this study, we investigated the effect of an array of compounds …
P450 3A4 (CYP3A4) gene. In this study, we investigated the effect of an array of compounds …
Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening
SJ Shukla, DT Nguyen, R MacArthur, A Simeonov… - 2010 - liebertpub.com
The human pregnane X nuclear receptor (PXR) is a xenobiotic-regulated receptor that is
activated by a range of diverse chemicals, including antibiotics, antifungals, glucocorticoids …
activated by a range of diverse chemicals, including antibiotics, antifungals, glucocorticoids …