Background The combination of sleep deprivation and light therapy, called combined
chronotherapy, may yield positive short-and long-term results, even in patients with …

Background There are a dozen studies on double or triple chronotherapy in depression
(sleep deprivation [wake therapy]+ light therapy+ sleep advance/stabilization). We …

Background Triple chronotherapy (wake night [one night without sleep], sleep phase
advance, and early morning bright light exposure) demonstrated rapid efficacy primarily in …

There is an urgent need for rapid, effective, and safe treatments for bipolar depression.
Triple chronotherapy is a combination of sleep deprivation, sleep phase advance, and bright …

Depression is a significant public health issue, made worse by the absence of response to
antidepressant medications by many patients. Given the high degree of overlap between …

BACKGROUND: Drug-resistant depression is a major therapeutic issue in psychiatry and
the development of non-drug therapies that treat drug-resistant depression is required …

Previous studies have demonstrated that combined total sleep deprivation (Wake therapy),
sleep phase advance, and bright light therapy (Triple Chronotherapy) produce a rapid and …

Background Given the strong relationship between circadian rhythm disruption and mood
regulation, combined chronotherapeutic approaches have been proposed for mood …

There is growing evidence for combined chronotherapeutic interventions as adjunctive
treatments for major depression. However, as the treatments can be demanding, we need to …

Background Triple chronotherapy (sleep deprivation for 36 h, followed by 4 days of
advancing the time of sleep and daily morning bright-light therapy for 6 months) has …